Effect of Vitamin C on Allergy Skin Test

NCT05810233 | Unknown

• 1 other identifier: JEP-2023
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study will assess the effect of taking vitamin C on allergy skin test.

Conditions

Rhinitis, Allergic; Allergy

Keywords

ascorbic acid; skin prick test; vitamin C; antihistamine

Outcome Measures

Primary Outcomes (1)

• Skin prick test wheal area of vitamin C group compared to placebo

  Skin wheal reaction is measured using computer software. Day 8 wheal area of vitamin C group compared to placebo.

  Day 8

Secondary Outcomes (1)

• Skin prick test wheal reaction at day 8 of intevention compraed to prior skin prick test done as standard of care

  Day 8

Study Arms (2)

Vitamin C

EXPERIMENTAL

Commercially available Tablet Vitamin C 1000mg per day for 7 days

Dietary Supplement: Ascorbic acid 1000mg

Placebo

PLACEBO COMPARATOR

Glucose chewable table 1x per day for seven days

Other: Placebo

Interventions

Ascorbic acid 1000mg DIETARY_SUPPLEMENT

Health supplement

Also known as: VItamin C

Vitamin C

Placebo OTHER

Glucose chewable tablet without any ascorbic acid

Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Participants above 18-years old
• Participants with history at least 2 symptoms of rhinitis triggered by dust
• Positive SPT to Dermatophagoides pteronyssinus with wheal reaction of at least 5 mm done within the past 1 year.

You may not qualify if:

• Prior skin prick test result form do not include a tracing of the wheal reaction.
• Prior skin prick test was not performed in HCTM.
• Participants who are actively smoking or who have smoked cigarette or vaped in the past 6 months
• Participants with skin conditions affecting the volar aspects of the arm.
• Participants on beta-blockers
• Participants contraindicated for skin prick test (pregnancy, history of anaphylaxis, poorly controlled asthma)
• Participants on long term supplements (multivitamin, traditional supplement)
• Participants contraindicated for vitamin c (vitamin c allergy, kidney dysfunction, history of kidney or bladder stones, hyperuricemia, thalassemia, G6PD deficiency, sickle cell disease, hamatochromatosis)
• Participants at risk of vitamin C deficiency (hyperthyroidism, elderly, beastfeeding, diarrhoea, restricted diet secondary to inflammatory bowel disease, anorexia or cancer)

Sponsors & Collaborators

• National University of Malaysia: lead

Study Sites (1)

Hospital Canselor Tuanku Mukhriz

Cheras, WP Kuala Lumpur, 56000, Malaysia

RECRUITING

Related Publications (2)

• Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S2-8. doi: 10.1067/mai.2001.115569.

  PMID: 11449200 BACKGROUND

• Fortner BR Jr, Danziger RE, Rabinowitz PS, Nelson HS. The effect of ascorbic acid on cutaneous and nasal response to histamine and allergen. J Allergy Clin Immunol. 1982 Jun;69(6):484-8. doi: 10.1016/0091-6749(82)90171-3.

  PMID: 7076989 BACKGROUND

MeSH Terms

Conditions

Rhinitis, Allergic; Hypersensitivity

Interventions

Ascorbic Acid

Condition Hierarchy (Ancestors)

Rhinitis; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Immune System Diseases

Intervention Hierarchy (Ancestors)

Sugar Acids; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Hydroxy Acids; Carbohydrates

Study Officials

• Aneeza K W Hamizan

  National University of Malaysia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Aneeza K W Hamizan, MD

CONTACT

0391455555; draneeza@ukm.edu.my

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Tablets will be despensed by a research assistant
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Dr

Model Details: Participant assigned to only one intervention per arm either vitamin C or placebo tablets

Study Record Dates

• First Submitted: March 30, 2023
• First Posted: April 12, 2023
• Study Start: July 15, 2023
• Primary Completion: September 30, 2023
• Study Completion: January 30, 2024
• Last Updated: August 30, 2023

Record last verified: 2023-08

Locations

MY (1)