Rehabilitation Treatment of Patients With COVID-19

NCT05808361 | Completed

• 1 other identifier: COVID-REHAB
• Study Type: interventional
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

This is single centre retrospective study with propensity score matching. The aim of the study is to develop criteria for determining groups of patients with a new coronavirus infection based on clinical, laboratory and instrumental data for whom rehabilitation programs (physical exercises, chest massage in an electrostatic field) will be effective. Data on predictors of effective rehabilitation in COVID-19 is limited. Knowledge of predictors of possibility and efficacy of rehabilitation programs could enhance patients recovery. The main symptoms of COVID-19 involve the respiratory system and psychological function. Early rehabilitation can reduce hospital length of stay. Different patients have different degrees of dysfunction; therefore, personal plans should be developed according to the patient's age, sex, lifestyle and physical condition. Regular follow-up and rehabilitation guidance were conducted for discharged patients, focusing on improving vital capacity and cardiopulmonary endurance. There is a clear consensus that early rehabilitation is an important strategy for the treatment of polyneuropathy and myopathy in critical disease, to facilitate and improve long-term recovery and patients' functional independence, and to reduce the duration of respiratory support and hospitalization. Early rehabilitation and exercise prescriptions remain to be further optimized, especially for hospitalised patients.

Conditions

Rehabilitation; Pneumonia, Viral; COVID-19; Quality of Life

Outcome Measures

Primary Outcomes (1)

• Length of stay in hospital

  length of stay in hospital

  30 days

Secondary Outcomes (6)

• complete blood count

  Change of white blood cells from baseline on day 7 during treatment

• complete blood count dynamics

  Change of white blood cells from 7 to 14 day during treatment

• Complaints of fatigue

  Change of complains from baseline on day 7 during treatment

• Complaints of fatigue dynamics

  Change of complains from 7 to 14 day during treatment

• Biochemistry analysis

  Change of CRP from baseline on day 7 during treatment

Study Arms (3)

physical exercise

EXPERIMENTAL

Rehabilitation program includes physical exercises, started in the first 3 days after the patient's body temperature returned to normal.

Other: exercises

exercises and massage

EXPERIMENTAL

Rehabilitation programs include physical exercises, and chest massage in an electrostatic field, started in the first 3 days after the patient's body temperature returned to normal.

Other: exercises; Other: massage

Control

NO INTERVENTION

Patients received treatment according to the temporary guideline without any rehabilitation program.

Interventions

exercises OTHER

The complex of therapeutic exercises included exercises in the initial position lying, sitting and standing. In active and static motor modes under the control of saturation, blood pressure, heart rate and respiratory rate. The complex included breathing exercises with the inclusion of compensatory respiratory muscles, elements of sound and drainage gymnastics, and diaphragmatic breathing. Therapeutic gymnastics was carried out in the form of individual lessons with an exercise therapy instructor, a course of 10 procedures, daily, the duration was 20 minutes.

exercises and massage; physical exercise

massage OTHER

Hardware massage in the electrostatic field with a frequency of 30/60 Hz of the chest area consisted of 10 procedures, daily, the duration of the procedure was 20 minutes.

exercises and massage

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients with COVID-19 admitted to the hospital with mild or moderate COVID-19 (5-50% of lung damage according to CT-scan)

You may not qualify if:

• less than 7 days in hospital by any reason,
• chronic decompensated diseases with extrapulmonary organ dysfunction (tumour progression, liver cirrhosis, congestive heart failure), admission to ICU, atonic coma,
• patients in whom more than 30 days have passed since the onset of the disease and before hospitalization,
• patients who received treatment in the intensive care unit, as well as patients who died.

Sponsors & Collaborators

• I.M. Sechenov First Moscow State Medical University: lead
• MEDSI Clinical Hospital 1, ICU: collaborator

Study Sites (1)

Clinical Hospital "MEDSI" in Otradnoe

Moscow, 143442, Russia

Location

Related Publications (2)

• Sun T, Guo L, Tian F, Dai T, Xing X, Zhao J, Li Q. Rehabilitation of patients with COVID-19. Expert Rev Respir Med. 2020 Dec;14(12):1249-1256. doi: 10.1080/17476348.2020.1811687. Epub 2020 Oct 12.

  PMID: 32799694 BACKGROUND

• Demeco A, Marotta N, Barletta M, Pino I, Marinaro C, Petraroli A, Moggio L, Ammendolia A. Rehabilitation of patients post-COVID-19 infection: a literature review. J Int Med Res. 2020 Aug;48(8):300060520948382. doi: 10.1177/0300060520948382.

  PMID: 32840156 BACKGROUND

MeSH Terms

Conditions

Pneumonia, Viral; COVID-19

Interventions

Exercise; Massage

Condition Hierarchy (Ancestors)

Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Lung Diseases; Respiratory Tract Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Therapy, Soft Tissue; Musculoskeletal Manipulations; Complementary Therapies; Therapeutics; Physical Therapy Modalities; Rehabilitation

Study Officials

• Danil Maliutin, MD

  Clinical Hospital "MEDSI" in Otradnoe

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 7, 2023
• First Posted: April 11, 2023
• Study Start: April 1, 2020
• Primary Completion: June 15, 2021
• Study Completion: June 15, 2021
• Last Updated: April 12, 2023

Record last verified: 2023-04

Locations

RU (1)