Prevention and Rehabilitation of Stroke in Uganda

NCT05807269 | Recruiting

• 1 other identifier: 2022-04303
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

Stroke is increasing in low-income countries in Africa, and knowledge is lacking on risk factors and how to prevent stroke as well as how to best use the resources for rehabilitation after stroke which are very limited. Knowledge generation within this area is therefore urgently needed. This collaboration between the research group HELD (Health and Everyday Life among people with neurological Disorders), Karolinska Institutet (KI) and the research surveillant site Africa Medical and Behavioral Sciences Organization (AMBSO) population health surveillance (PHS), will create substantial research opportunities to develop and improve prevention and rehabilitation for stroke, which is in line with the sustainable development goals to reduce the prevalence and mortality rates due to NCDs. AMBSO is collecting data from 17 000 households on many potential risk factors for stroke. Questions about stroke primary and secondary prevention of stroke and impact of stroke or need of rehabilitation could be added to the existing questionnaires such as the validated Ugandan version of the Stroke Impact Scale. This is intended to fulfill the aim of the network which is to increase the knowledge of occurrence and consequences of NCDs with a specific focus on stroke, which will be valuable for the development of preventive healthcare policy documents and guidelines for appropriate prevention strategies and rehabilitation interventions. Research questions in relation to NCDs with focus on stroke prevention and rehabilitation:

• How many cases (prevalence) are reported in the targeted study sites and what is the mortality rate (incidence) that can specifically relate to stroke?
• How does stroke and other NCDs affect and impact the quality of life for persons living in Uganda?
• Which factors impact the recovery process after stroke?
• What sort of rehabilitation is needed in the study areas for persons affected by stroke? In addition, risk factors of stroke such as diabetes and hypertension will be mapped.

Conditions

Stroke

Outcome Measures

Primary Outcomes (2)

• Stroke Impact Scale-16

  Questionnaire comprising 16 statements concerning perceived impact of stroke. Each item is rated on a scale from 0 (high impact) to 5 (no impact).

  At one assessment point during 2023-2024

• Stroke Impact Scale, perceived recovery

  Perceived recovery after stroke is rated on a visual analogue scale ranging from 0 (no recovery) to 100 (full recovery).

  At one assessment point during 2023-2024

Secondary Outcomes (6)

• Life Satisfaction Checklist (LISat-11)

  At one assessment point during 2023-2024

• Patient Health Questionnaire-9

  At one assessment point during 2023-2024

• Generalized Anxiety Disorder Assessment-7

  At one assessment point during 2023-2024

• Health Literacy Questionnaire

  At one assessment point during 2023-2024

• Use of health care services

  At one assessment point during 2023-2024

Study Arms (1)

People with stroke

Participants with stroke or risk factors for stroke

Eligibility Criteria

• Age: 13 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community sample from Wasiko and Hoima in Uganda

You may qualify if:

• Stroke
• Risk factors for stroke: hypertension, diabetes, HIV, malaria, physical inactivity, obesity

You may not qualify if:

• Not having had stroke and/or having no risk factor for stroke

Sponsors & Collaborators

• Karolinska Institutet: lead
• The Swedish Research Council: collaborator

Study Sites (2)

AMBSO, Hoima

Hoima, Uganda

RECRUITING

AMBSO, Wakiso

Kampala, Uganda

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Gunilla Eriksson, PhD

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Gunilla Eriksson, PhD

CONTACT

+46702216924; gunilla.eriksson@ki.se

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: March 13, 2023
• First Posted: April 11, 2023
• Study Start: November 1, 2023
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: April 11, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

UG (2)