NCT05805345

Brief Summary

The purpose of this study is to compare the fit characteristics between four Alcon commercially available toric contact lenses.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Apr 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

7 active sites

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 23, 2023

Completed
9 days until next milestone

Study Start

First participant enrolled

April 1, 2023

Completed
9 days until next milestone

First Posted

Study publicly available on registry

April 10, 2023

Completed
21 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2023

Completed
Last Updated

May 19, 2023

Status Verified

May 1, 2023

Enrollment Period

1 month

First QC Date

March 23, 2023

Last Update Submit

May 18, 2023

Conditions

Keywords

Contact Lenses

Outcome Measures

Primary Outcomes (1)

  • Distance VA with study lenses

    Visual Acuity (VA) will be assessed using letter charts with study lenses in place and reported in logarithm minimum angle of resolution (logMAR). A logMAR value of 0.0 equates to 20/20 Snellen, which is considered normal distance eyesight. Eyes will be assessed individually.

    30 mins (± 15 mins), each product

Study Arms (4)

DT1fA/T30fA/AOHGfA/P1fA

OTHER

DT1fA worn first, followed by T30fA, as randomized, during the first wear period, with AOHGfA worn first, followed by P1fA during the second wear period. Each lens type will be worn in both eyes for approximately 30 minutes. The wear periods will be separated by 1 to 9 days.

Device: Delefilcon A toric soft contact lensDevice: Lehfilcon A toric soft contact lensDevice: Lotrafilcon B toric soft contact lensDevice: Verofilcon A toric soft contact lens

T30fA/AOHGfA/P1fA/DT1fA

OTHER

T30fA worn first, followed by AOHGfA, as randomized, during the first wear period, with P1fA worn first, followed by DT1fA during the second wear period. Each lens type will be worn in both eyes for approximately 30 minutes. The wear periods will be separated by 1 to 9 days.

Device: Delefilcon A toric soft contact lensDevice: Lehfilcon A toric soft contact lensDevice: Lotrafilcon B toric soft contact lensDevice: Verofilcon A toric soft contact lens

AOHGfA/P1fA/DT1fA/T30fA

OTHER

AOHGfA worn first, followed by P1fA, as randomized, during the first wear period, with DT1fA worn first, followed by T30fA during the second wear period. Each lens type will be worn in both eyes for approximately 30 minutes. The wear periods will be separated by 1 to 9 days.

Device: Delefilcon A toric soft contact lensDevice: Lehfilcon A toric soft contact lensDevice: Lotrafilcon B toric soft contact lensDevice: Verofilcon A toric soft contact lens

P1fA/DT1fA/T30fA/AOHGfA

OTHER

P1fA worn first, followed by DT1fA, as randomized, during the first wear period, with T30fA worn first, followed by AOHGfA during the second wear period. Each lens type will be worn in both eyes for approximately 30 minutes. The wear periods will be separated by 1 to 9 days.

Device: Delefilcon A toric soft contact lensDevice: Lehfilcon A toric soft contact lensDevice: Lotrafilcon B toric soft contact lensDevice: Verofilcon A toric soft contact lens

Interventions

Commercially available silicone hydrogel contact lens

Also known as: DT1fA, DAILIES TOTAL1® for Astigmatism
AOHGfA/P1fA/DT1fA/T30fADT1fA/T30fA/AOHGfA/P1fAP1fA/DT1fA/T30fA/AOHGfAT30fA/AOHGfA/P1fA/DT1fA

Commercially available silicone hydrogel contact lens

Also known as: T30fA, TOTAL30™ for Astigmatism
AOHGfA/P1fA/DT1fA/T30fADT1fA/T30fA/AOHGfA/P1fAP1fA/DT1fA/T30fA/AOHGfAT30fA/AOHGfA/P1fA/DT1fA

Commercially available silicone hydrogel contact lens

Also known as: AOHGfA, AIR OPTIX® plus HydraGlyde® for Astigmatism
AOHGfA/P1fA/DT1fA/T30fADT1fA/T30fA/AOHGfA/P1fAP1fA/DT1fA/T30fA/AOHGfAT30fA/AOHGfA/P1fA/DT1fA

Commercially available silicone hydrogel contact lens

Also known as: P1fA, PRECISION1® for Astigmatism
AOHGfA/P1fA/DT1fA/T30fADT1fA/T30fA/AOHGfA/P1fAP1fA/DT1fA/T30fA/AOHGfAT30fA/AOHGfA/P1fA/DT1fA

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Successful wear of toric soft contact lenses in both eyes for a minimum of 5 days per week and 10 hours per day during the past 3 months.
  • Able to be fit with contact lenses within the available range of sphere, cylinder power, and axes (based on lens availability).
  • Best Corrected Visual Acuity (BCVA) better than or equal to 0.10 (logMAR) in each eye.
  • Willing to stop wearing habitual contact lenses during in-office visits.

You may not qualify if:

  • Current spherical, monovision or multifocal lens wearer.
  • Protocol-specified biomicroscopy findings at screening.
  • Current or history of herpetic keratitis in either eye.
  • Participation in a clinical trial within the previous 30 days or currently enrolled in any clinical trial.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (7)

Kurata Eyecare Center

Los Angeles, California, 90013, United States

Location

Omega Vision Center P.A.

Longwood, Florida, 32779, United States

Location

Kindred Optics at Maitland Vision

Maitland, Florida, 32751, United States

Location

Kannarr Eye Care LLC

Pittsburg, Kansas, 66762, United States

Location

ProCare Vision Centers, Inc.

Granville, Ohio, 43023, United States

Location

Optometry Group, PLLC

Memphis, Tennessee, 38111, United States

Location

Clarke EyeCare Center

Wichita Falls, Texas, 76308, United States

Location

MeSH Terms

Conditions

AstigmatismRefractive Errors

Condition Hierarchy (Ancestors)

Eye Diseases

Study Officials

  • Clinical Trial Lead, Vision Care

    Alcon Research, LLC

    STUDY CHAIR
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 23, 2023

First Posted

April 10, 2023

Study Start

April 1, 2023

Primary Completion

May 1, 2023

Study Completion

May 1, 2023

Last Updated

May 19, 2023

Record last verified: 2023-05

Data Sharing

IPD Sharing
Will not share

Locations