Operant Conditioning of Reflex Pathways to Improve Walking in Individuals Post-stroke

NCT05801744 | Unknown

• 1 other identifier: 1656292
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the changes in reflex pathways in the paretic ankle plantarflexors in individuals with post-stroke hemiparesis using operant conditioning. We are recruiting 5 individuals with chronic post-stroke hemiparesis with foot drop in the affected leg to participate in the reflex training procedure. The study involves 40 visits with a total study duration of about 4 months.

Conditions

Stroke; Post-stroke Hemiparesis; Foot Drop

Outcome Measures

Primary Outcomes (1)

• Change in magnitude of reciprocal inhibition

  Before training Baseline, after completion of 30 training sessions, and 1 month after the completion of intervention

Study Arms (1)

Reciprocal inhibition up conditioning

EXPERIMENTAL

Each participant completes 6 baseline sessions and 30 up conditioning sessions. In the 30 conditioning sessions, the magnitude of reciprocal inhibition in the paretic leg of participants post-stroke will be up conditioned.

Behavioral: Operant conditioning

Interventions

Operant conditioning BEHAVIORAL

In this training, individuals with post-stroke hemiparesis are trained to increase the amount of reciprocal inhibition in their paretic leg. By increasing the amount of reciprocal inhibition, the paretic ankle in people post-stroke may exhibit less foot drop.

Reciprocal inhibition up conditioning

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 6 months following a single, unilateral stroke, resulting in hemiparesis.
• Ambulatory with or without assistive device, but must demonstrate a gait deficit which is indicative of foot drop from reduced activation of the tibialis anterior muscle.
• Able to follow verbal directions.
• Able to see icons on computer monitor (with or without corrective lenses) from at least 4 feet away.
• All subjects will be adults at least 18 years old.
• Know history and current medication management for lower limb spasticity, if any.

You may not qualify if:

• No history of ear disease or balance problems outside of those caused by the stroke.
• Cerebellar stroke
• No other neurological disease or injuries other than the stroke affecting the use of the legs and/or walking.

Sponsors & Collaborators

• University of Nevada, Las Vegas: lead

Study Sites (1)

University of Nevada, Las Vegas

Las Vegas, Nevada, 89154, United States

RECRUITING

MeSH Terms

Conditions

Stroke; Peroneal Neuropathies

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2023
• First Posted: April 6, 2023
• Study Start: August 1, 2022
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: April 6, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)