Preoperative Cognitive Impairment Predicts Postoperative Delirium

NCT05798767 | Completed

• 1 other identifier: PCI and POD
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Preoperative cognitive impairment (PCI) may increase the incidence of postoperative delirium (POD), yet screening for cognitive impairment is rarely performed. This study hypothesized that Mini-Cog for preoperative cognitive impairment screening predicts postoperative delirium. Elderly patients (65 years or older) attending Henan Provincial People's Hospital during the trial period who required elective thoracic surgery were recruited into the study.

Conditions

Delirium in Old Age; Neurocognitive Disorders; Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• delirium

  postoperative delirium accessed by the Short Confusion Assessment Method (CAM)

  February 2022 to March 2023

Study Arms (2)

PCI group

Patients with a Mini-Cog score of 3 or less were in the PCI group

Behavioral: Neuropsychological tests

Normal group

Patients with a Mini-Cog score of 3 or 4 were in the normal group

Behavioral: Neuropsychological tests

Interventions

Neuropsychological tests BEHAVIORAL

Cognitive function screening (Mini-Cog; the Mini-mental State Examination, MMSE), depression screening (Patient Health Questionnaire-9, PHQ-9), sleep quality assessment (Pittsburgh Sleep Quality Index, PSQI), and pain assessment (Numeric Rating Scale, NRS) were performed the day before surgery. The Short Confusion Assessment Method (CAM) was administered once per day on postoperative days 1 to 5 to evaluate delirium.

Normal group; PCI group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly patients attending Henan Provincial People's Hospital during the trial period who required elective thoracic surgery

You may qualify if:

• years of age or older,
• elective thoracic surgery,
• under general anesthesia.

You may not qualify if:

• history of psychiatric disorders,
• use of any antipsychotic drugs,
• ASA score \>3
• severe visual, hearing, or physical dysfunction unable to complete the scale
• advanced malignant tumors of the chest with distant metastases to bone, liver, etc.,
• history of general anesthesia surgery in the last six months.

Sponsors & Collaborators

• Henan Provincial People's Hospital: lead

Study Sites (1)

Henan People's Hospital

Zhengzhou, China

Location

Related Publications (1)

• Li F, Miao M, Li N, Zhou J, Sun M, Zhang J. Prevalence of preoperative cognitive impairment among elderly thoracic surgery patients and association with postoperative delirium: a prospective observational study. Front Hum Neurosci. 2023 Jul 20;17:1234018. doi: 10.3389/fnhum.2023.1234018. eCollection 2023.

  PMID: 37545595 DERIVED

MeSH Terms

Conditions

Neurocognitive Disorders; Cognitive Dysfunction

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Mental Disorders; Cognition Disorders

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2023
• First Posted: April 5, 2023
• Study Start: February 1, 2022
• Primary Completion: January 1, 2023
• Study Completion: March 1, 2023
• Last Updated: April 5, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)