Effects of Graft Vascular Dimensions on Surgical and Functional Outcomes of Living Donor Kidney Transplantation

NCT05797389 | Unknown

• 1 other identifier: vascular dimensions and KT
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Correlate the radiological and intraoperative measuring of the vascular dimensions,
2. 2.Assess the effect of the vascular dimensions on the short-term surgical complications and
3. 3.Assess the effect of the vascular dimensions on the primary graft function in pediatric and adults KTs.

Conditions

Kidney Transplant; Complications

Keywords

kidney transplantation; renal transplantation; vascular dimensions; vascular parameters

Outcome Measures

Primary Outcomes (2)

• Mode of graft function defined by: 1- the time of start of diuresis post-transplantation.

  Mode of graft function defined by: 1- the start of diuresis (sufficient amount of urine production) within one hour of declamping through the first week post-transplantation

  one month post operative.

• 2- Rate of decline of the serum creatinine level.

  2- Rate of decline of the serum creatinine level.

  one month post operative.

Secondary Outcomes (2)

• The rate of vascular complications (intra- or perioperative).

  one month post operative

• The rate of other surgical complications.

  one month post operative

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric and adult patients undergoing living donor kidney transplantation.

You may qualify if:

• Pediatric and adult patients undergoing living donor kidney transplantation.

You may not qualify if:

• Patients with acute graft rejection occurring within the first week of transplantation.
• Patients refusing participation in the study.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (10)

• Srivastava A, Kumar J, Sharma S, Abhishek, Ansari MS, Kapoor R. Vascular complication in live related renal transplant: An experience of 1945 cases. Indian J Urol. 2013 Jan;29(1):42-7. doi: 10.4103/0970-1591.109983.

  PMID: 23671364 BACKGROUND

• Fananapazir G, Troppmann C. Vascular complications in kidney transplant recipients. Abdom Radiol (NY). 2018 Oct;43(10):2546-2554. doi: 10.1007/s00261-018-1529-9.

  PMID: 29500646 BACKGROUND

• Dimitroulis D, Bokos J, Zavos G, Nikiteas N, Karidis NP, Katsaronis P, Kostakis A. Vascular complications in renal transplantation: a single-center experience in 1367 renal transplantations and review of the literature. Transplant Proc. 2009 Jun;41(5):1609-14. doi: 10.1016/j.transproceed.2009.02.077.

  PMID: 19545690 BACKGROUND

• Kadakia Y, Hwang C, MacConmara M. Rescue of an asymptomatic arterial occlusion after kidney transplant. BMJ Case Rep. 2022 Feb 7;15(2):e247347. doi: 10.1136/bcr-2021-247347.

  PMID: 35131794 BACKGROUND

• Meltzer AZ, Fintha A, Cseprekal O, Somogyi D, Szabo J, Kobori L, Rozsa B, Piros L, Huszty G. Graft Arterial Dissection and Thrombosis After Kidney Transplantation With Undiagnosed Fibromuscular Dysplasia From a Deceased Donor: Case Report and Review. Transplant Proc. 2022 Nov;54(9):2603-2607. doi: 10.1016/j.transproceed.2022.10.049. Epub 2022 Nov 16.

  PMID: 36400588 BACKGROUND

• Singh D, Butala BP, Parikh GP. Acute renal artery spasm during live kidney transplant surgery due to iatrogenic cause. Saudi J Kidney Dis Transpl. 2016 Mar;27(2):415-6. doi: 10.4103/1319-2442.178588. No abstract available.

  PMID: 26997403 BACKGROUND

• Sevmis M, Demir ME, Merhametsiz O, Aktas S, Sevmis S, Uyar M. Grafts With Multiple Renal Arteries in Kidney Transplantation. Transplant Proc. 2021 Apr;53(3):933-940. doi: 10.1016/j.transproceed.2020.07.019. Epub 2020 Sep 17.

  PMID: 32950261 BACKGROUND

• Ali-El-Dein B, Osman Y, Shokeir AA, Shehab El-Dein AB, Sheashaa H, Ghoneim MA. Multiple arteries in live donor renal transplantation: surgical aspects and outcomes. J Urol. 2003 Jun;169(6):2013-7. doi: 10.1097/01.ju.0000067637.83503.3e.

  PMID: 12771707 BACKGROUND

• Osman Y, Shokeir A, Ali-el-Dein B, Tantawy M, Wafa EW, el-Dein AB, Ghoneim MA. Vascular complications after live donor renal transplantation: study of risk factors and effects on graft and patient survival. J Urol. 2003 Mar;169(3):859-62. doi: 10.1097/01.ju.0000050225.74647.5a.

  PMID: 12576799 BACKGROUND

• Riella J, Tabbara MM, Alvarez A, DeFreitas MJ, Chandar J, Gaynor JJ, Gonzalez J, Ciancio G. Pediatric kidney transplants with multiple renal arteries show no increased risk of complications compared to single renal artery grafts. Front Pediatr. 2022 Dec 16;10:1058823. doi: 10.3389/fped.2022.1058823. eCollection 2022.

  PMID: 36589161 BACKGROUND

Central Study Contacts

Mohamed L Shehata

CONTACT

00201093590017; mohamed.l.m.sh@gmail.com

Rabea A Gadelkareem

CONTACT

00201001529356; dr.rabeagad@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: March 21, 2023
• First Posted: April 4, 2023
• Study Start: April 1, 2023
• Primary Completion: March 1, 2025
• Study Completion: April 1, 2025
• Last Updated: April 4, 2023

Record last verified: 2023-04