NCT05796843

Brief Summary

The goal of this randomized controlled trial is to compare the effects of 360 degree virtual reality-based mirror therapy (360MT) to traditional mirror therapy (TMT) and conventional physical therapy (control group) on upper extremity function among stroke patients. The main questions it aims to answer are:

  • Would 360MT be more effective when treated for 4 weeks in outcome measure ments including: Fugl-Meyer Assessment for upper extremity (FMA-UE); manual function test (MFT); and box \& block test (BBT)?
  • How would particants' experience be in terms of satisfactory and enjoyment during 360MT? The study will have three groups of participants who will be involved in different tasks:
  • 360MT group: will receive mirror therapy using a virtual reality device (HMD) and perform tasks with their paralyzed hand. Sessions will last 30 minutes, 3 times a week for 4 weeks.
  • TMT group: will receive mirror therapy using an acrylic mirror and perform finger, wrist, elbow exercises using their paralyzed limb. Sessions will last 30 minutes, 3 times a week for 4 weeks.
  • Control group: will receive conventional physical therapy consisting of exercises for the upper extremity, 60 minutes per day, 5 sessions a week, for 4 weeks.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
45

participants targeted

Target at P50-P75 for not_applicable stroke

Timeline
Completed

Started Apr 2023

Shorter than P25 for not_applicable stroke

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 16, 2023

Completed
16 days until next milestone

Study Start

First participant enrolled

April 1, 2023

Completed
3 days until next milestone

First Posted

Study publicly available on registry

April 4, 2023

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 4, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 4, 2023

Completed
Last Updated

May 6, 2023

Status Verified

May 1, 2023

Enrollment Period

1 month

First QC Date

March 16, 2023

Last Update Submit

May 4, 2023

Conditions

Keywords

StrokeStroke RehabilitationMirror Movement Therapy

Outcome Measures

Primary Outcomes (1)

  • Fugl-Meyer Assessment for upper extremity (FMA-UE)

    The test is one of the most frequently used evaluation tools that quantitatively assesses recovery after stroke by measuring motor skills, balance ability, sensory function, and range of motion. The maximum total score for FMA-UE is 66 points, containing 18 items to evaluate shoulder, elbow, and forearm; 5 for the wrist; 7 for the hand; and 3 items for coordination.

    Changes from baseline after 4 weeks of intervention

Secondary Outcomes (2)

  • Manual Function Test (MFT)

    Changes from baseline after 4 weeks of intervention

  • Box & Block Test (BBT)

    Changes from baseline after 4 weeks of intervention

Study Arms (3)

360 Degrees Virtual Reality-based Mirror Therapy Group

EXPERIMENTAL

The group which will receive 360 Degrees Virtual Reality-based Mirror Therapy Group

Procedure: 360 Degrees virtual reality-based mirror therapyProcedure: Conventional Physical Therapy

Traditional Mirror Therapy Group

ACTIVE COMPARATOR

The group which will receive traditional mirror therapy using a conventional mirror

Procedure: Traditional mirror therapyProcedure: Conventional Physical Therapy

Conventional Physical Therapy Group

ACTIVE COMPARATOR

The group which will receive conventional rehabilitation for upper extremity

Procedure: Conventional Physical Therapy

Interventions

Participants will receive mirror therapy using a virtual reality device (Pico G2 VR 4K, Pico, China). They will be asked to follow tasks that are played in HMD using their paralyzed hand. The video played using HMD will be video taped using 360 degree camera prior to the treatment. The 360MT will last 30 minutes/session, 3 sessions a week for 4 weeks. The tasks are finger flexion-extension, wrist flexion-extension and pronation-supination, and elbow flexion-extension for ten repetitions.

360 Degrees Virtual Reality-based Mirror Therapy Group

Participants will receive mirror therapy using an acrylic mirror (40cm x 40cm x 3cm) that reflects unparalyzed side of them. They will be asked to perform tasks including finger flexion-extension, wrist flexion-extension and pronation-supination, and elbow flexion-extension for ten repetitions. They will be asked to follow the reflection on mirror using their paralyzed limb. The TMT will last 30 minutes/session, 3 sessions a week for 4 weeks.

Traditional Mirror Therapy Group

Participants will receive conventional physical therapy including neurodevelopmental therapy, muscle strengthening exercises, and joint mobilization which will be provided 60 minutes per day, 5 sessions a week, for 4 weeks. The therapy will follow upper extremity rehabilitation protocol which consists of three phases of warm up, circuit, and cool down exercises

360 Degrees Virtual Reality-based Mirror Therapy GroupConventional Physical Therapy GroupTraditional Mirror Therapy Group

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • who have not passed 12 months since onset;
  • who can understand and follow instructions;
  • who have ≥21 scores in Korean version of Mini-Mental State Examination (MMSE-K);
  • who have mild to moderate motor impairment according to the Fugl Meyer Assessment (FMA) scores

You may not qualify if:

  • patients who have any kinds of mental disorder and/or Alzheimer's disease;
  • who have orthopedic and/or musculoskeletal injury;
  • who have apraxia; and
  • who have previous experiences of participating in investigations and/or mirror therapy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Myeonji Choonhae Hospital

Seoul, 07378, South Korea

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Sungbae Jo, PhD candidate

    Sahmyook University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Physical Therapist

Study Record Dates

First Submitted

March 16, 2023

First Posted

April 4, 2023

Study Start

April 1, 2023

Primary Completion

May 4, 2023

Study Completion

May 4, 2023

Last Updated

May 6, 2023

Record last verified: 2023-05

Data Sharing

IPD Sharing
Will not share

Locations