European Multicentric Study on Parathyroid Carcinoma

NCT05789680 | Unknown

• 1 other identifier: 5287
• Study Type: observational
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

The main aim of the study is to evaluate the incidence of post-operative diagnosis of PC and atypical parathyroid neoplasm in patients who underwent surgery for pHPT in different European centers using the EUROCRINE® database. Moreover, we aim to evaluate the peri-operative surgical characteristics, operation extent, postoperative morbidity, and outcomes in these patients category.

Conditions

Parathyroid Carcinoma

Keywords

parathyroid carcinoma; primary hyperparathyroidism; Eurocrine

Outcome Measures

Primary Outcomes (1)

• Incidence of parathyroid carcinoma

  Descriptive analysis of the exact incidence of parathyroid carcinoma among patients undergoing surgical treatment of primary hyperparathyroidism in European centers.

  January 2015-January 2021

Secondary Outcomes (1)

• Oncologic outcome

  January 2015-January 2021

Study Arms (1)

Parathyroid carcinoma among patients undergoing surgical treatment of primary hyperparathyroidism

All adult (18 years old and older) patients registered in EUROCRINE® database that underwent surgery for primary hyperparathyroidism and received histopathologic diagnosis of parathyroid carcinoma from 2015 till 2021 will be included

Procedure: Surgical treatment of parathyroid carcinoma

Interventions

Surgical treatment of parathyroid carcinoma PROCEDURE

Radical treatment of suspected parathyroid carcinoma should consist of parathyroidectomy and en bloc ipsilateral hemithyroidectomy and central lymph node dissection.

Also known as: parathyroidectomy, ipsilateral hemithyroidectomy, ipsilateral central neck dissection

Parathyroid carcinoma among patients undergoing surgical treatment of primary hyperparathyroidism

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with final histology of parathyroid carcinoma operated among European centers that participate in the Eurocrine® database between 2015 and 2021

You may qualify if:

• All adult (18 years old and older) patients
• underwent surgery
• final histology of parathyroid carcinoma
• among European centers that participate in the Eurocrine® database between 2015 and 2021

You may not qualify if:

• Patients \<18 years old

Sponsors & Collaborators

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS: lead

Study Sites (1)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Rome, 00168, Italy

RECRUITING

MeSH Terms

Conditions

Parathyroid Neoplasms; Hyperparathyroidism, Primary

Interventions

Parathyroidectomy

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms; Endocrine System Diseases; Parathyroid Diseases; Hyperparathyroidism

Intervention Hierarchy (Ancestors)

Endocrine Surgical Procedures; Surgical Procedures, Operative

Study Officials

• Marco Raffaelli, Prof

  Fondazione Policlinico Universitario Agostino Gemelli IRCCS

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Francesco Pennestrì, Dr

CONTACT

3280244528; francesco.pennestri@policlinicogemelli.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 16, 2023
• First Posted: March 29, 2023
• Study Start: December 15, 2022
• Primary Completion: June 1, 2023
• Study Completion: September 1, 2023
• Last Updated: March 29, 2023

Record last verified: 2023-02

Locations

IT (1)