NCT05784480

Brief Summary

Management of the reversible causes in cardiac arrest is fundamental for successful treatment of out-of-hospital cardiac arrests. Point-of-care diagnostics as prehospital emergency ultrasound, blood gas analysis and toxicological screening support the diagnostic process of evaluating potential reversible causes. Digital tools provide support of a structured approach. This study aims to evaluate the frequency of reversible causes during OHCA as well as specific interventions due to these findings. Furthermore, CPR performance (hands-off, ROSC, 30-day mortality) and cognitive load of the prehospital emergency physician will be investigated. In total 100 patients with OHCA will be included in this study. Identification of reversible causes will be performed upon a structured protocol using an interactive checklist. Cognitive load of emergency physician as well as CPR parameter (frequency of reversible causes, hands-off, ROSC, 30-day mortality) will be analysed.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
8mo left

Started Apr 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress83%
Apr 2023Dec 2026

First Submitted

Initial submission to the registry

January 6, 2023

Completed
3 months until next milestone

First Posted

Study publicly available on registry

March 27, 2023

Completed
5 days until next milestone

Study Start

First participant enrolled

April 1, 2023

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2025

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Expected
Last Updated

April 20, 2026

Status Verified

April 1, 2026

Enrollment Period

2.8 years

First QC Date

January 6, 2023

Last Update Submit

April 15, 2026

Conditions

Out-Of-Hospital Cardiac ArrestCardiopulmonary Arrest

Keywords

IntoxicationPrehospital POCUSCPRSonographyBlood gas analysisCardiac arrestOHCAReversible causesTele-supportChecklistPrehospital emergency physicianEmergency medicine

Outcome Measures

Primary Outcomes (1)

  • Frequency of reversible causes in OHCA and alterations of treatment

    The primary outcome of this study evaluates the frequency of reversible causes during OHCA.

    up to 30 days

Secondary Outcomes (4)

  • Frequency of ROSC

    up to 30 days

  • 30-day mortality

    up to 30 days

  • Hands-off time

    During study completion, up to 120 min

  • Cognitive load

    1 year (evaluation in documentation phase after CPR)

Study Arms (1)

Evaluation of reversible causes using digital checklist and diagnostic support

OTHER
Diagnostic Test: Checklist for evaluation of reversible causes

Interventions

Checklist for evaluation of reversible causesDIAGNOSTIC_TEST

Prehospital evaluation by checklist and diagnostic testing for reversible causes of OHCA using point-of-care blood gas analysis, saliva toxicological screen and ultrasound and post-hoc toxicological analysis of blood using mass spectrometry

Also known as: Venipuncture for toxicological screening, Point-of-Care blood gas analysis, Point-of-Care saliva toxicological screen, Point-of-care ultrasound
Evaluation of reversible causes using digital checklist and diagnostic support

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients with prehospital cardiac arrest, where POCUS, blood gas analysis as well as screening for intoxication can integrated in ALS rhythm without delay of life-saving treatment or transportation will be included.

You may not qualify if:

  • Patients will be excluded under the age of 18, or if POCUS, blood gas analysis will lead to a delay of live-saving treatment or transportation. Furthermore, pregnant patients will be excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Anesthesiology and Intensive Care Medicine Department - Medical University of Vienna

Vienna, 1090, Austria

Location

Department of Anesthesia, General Intensive Care and Pain Management,Medical University of Vienna

Vienna, 1090, Austria

Location

MeSH Terms

Conditions

Out-of-Hospital Cardiac ArrestHeart Arrest

Interventions

Phlebotomy

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Blood Specimen CollectionSpecimen HandlingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisPuncturesTherapeuticsSurgical Procedures, OperativeInvestigative Techniques

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 6, 2023

First Posted

March 27, 2023

Study Start

April 1, 2023

Primary Completion

December 31, 2025

Study Completion (Estimated)

December 31, 2026

Last Updated

April 20, 2026

Record last verified: 2026-04

Locations

AU(2)