To Study the Effects of Cordyceps Cicadae on Vision Care

NCT05778409 | Completed Early Phase 1 FDA Drug

• 1 other identifier: CRREC-111-087
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Cordyceps cicadae is a traditional Asian herbal medicine with a variety of bioactive substances and curative effects similar to Cordyceps Cicadae, and it has been reported that anti-dry eye and eye protection ingredients can be extracted. With the advancement of civilization, the number of patients with high myopia is increasing year by year and suffers from complications of dry eye or other eye diseases. In this study, the subjects were provided with cicadae extract or placebo in a double-blind manner, tracked the degree of visual fatigue by regular questionnaires, and measured for visual acuity, axial length and diopter. The purpose of this study is to investigate the effect of cicadae extract on visual acuity and visual fatigue, and to evaluate its potential as a health food ingredient.

Conditions

Myopia

Outcome Measures

Primary Outcomes (2)

• Eye fatigue questionnaire

  1. Eye fatigue were evaluated according to The Ocular Surface Disease Index (OSDI) introduced in 1997 by the Outcomes Research Group (Allergan Inc., Irvine, CA). 2. Content including: (1) Eye swelling, (2) Eye soreness, (3) Photophobia, (4) Blurred vision, (5) Dry eye, (6) Foreign body sensation, (7) Tearing, (8) General discomfort related to eye fatigue. 3. Scores are expressed on a scale of 0-3. 0 = No symptoms , 1 = Occasionally (≤1 time/day), 2 = Sometimes (1-3 times/day), 3 = Frequently (\>3 times/day), a low score means less visual fatigue and better eye quality.

  one month

• Best vision test

  1. Visual acuity was tested with the Snellen Eye Test Chart and recorded with the score proposed by Snellen. 2. Subjects were asked to stand 20 feet away to observe the snellen E-chart and record the smallest visual mark. 3. Recording method: 20/20 (1.0) is defined as normal vision, lower than this score indicates that the subject has ametropia, and higher than this indicates that the subject's vision is higher than the general standard

  one month

Study Arms (1)

Cordyceps Cicadae extract group

EXPERIMENTAL

500 mg/ day for 1 month

Biological: Cordyceps cicadae extract

Interventions

Cordyceps cicadae extract BIOLOGICAL

500mg/ day for one month

Cordyceps Cicadae extract group

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 20 or over
• Willing to participate in this study and sign the subject's consent form
• Myopia less than 700 degrees

You may not qualify if:

• Have consumed related eye care products in past 3 months
• Those who have eye infection in the past 3 months
• People who have been diagnosed with any eye diseases in past 3 months
• Those who are allergic to cicadae

Sponsors & Collaborators

• China Medical University Hospital: lead

Study Sites (1)

Asia university

Taichung, 413, Taiwan

Location

MeSH Terms

Conditions

Myopia

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases

Study Officials

• Hui-Wen Lin, Ph.D

  Asia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: March 8, 2023
• First Posted: March 21, 2023
• Study Start: March 8, 2023
• Primary Completion: April 14, 2023
• Study Completion: August 31, 2023
• Last Updated: June 25, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)