NCT05774847

Brief Summary

This behavioral study on healthy participants aims to provide a baseline reference for assessing alterations of decision-making performance in pathological conditions. To this purpose, this single center non-interventional behavioral study will assess the extent to which decision-making performance is affected by distinct experimental manipulations, as well as by ageing effects, in 200 healthy individuals. The main questions it aims to answer are:

  • to what extent is decision-making performance stable, within individuals, regardless of non-economic manipulations concerning stimuli perceptual features as well as type of processing and motor response required to participants?
  • are these manipulations additionally influenced by participants' age? Healthy participants will be recruited for distinct behavioral studies assessing the effects of the aforementioned manipulations of distinct metrics of decision-making performance, such as loss aversion, risk aversion, and delay discounting.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
18mo left

Started May 2021

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress77%
May 2021Oct 2027

Study Start

First participant enrolled

May 24, 2021

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

March 7, 2023

Completed
13 days until next milestone

First Posted

Study publicly available on registry

March 20, 2023

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2027

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2027

Last Updated

April 8, 2026

Status Verified

April 1, 2025

Enrollment Period

5.9 years

First QC Date

March 7, 2023

Last Update Submit

April 7, 2026

Conditions

Keywords

decision-makingunconscious processingsubliminal processing

Outcome Measures

Primary Outcomes (1)

  • Individual index of loss aversion

    This variable reflect the spontaneous disposition to overweigh potential losses, compared with equivalent gains in decision-making, resulting in the tendency to avoid potential losses more than approach potential gains.

    Behavioral-study day 1

Secondary Outcomes (2)

  • Individual index of risk aversion

    Behavioral-study day 1

  • Individual index of delay discounting

    Behavioral-study day 1

Study Arms (1)

All healthy participants

Healthy participants will be recruited and assigned to different behavioral studies assessing the effect of the experimental manipulations of interest on decision-making metrics.

Other: No intervention

Interventions

No intervention

All healthy participants

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Age GroupsAdult (18-64)
Sampling MethodProbability Sample
Study Population

200 healty individuals, aged 18-60 years, sampled from the general population

You may qualify if:

  • Healthy participants, as determined by screening assessments and principal investigator judgment
  • The participant must be able to comply with study requirements as judged by the principal investigator

You may not qualify if:

  • Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse
  • Use of any psychoactive medication, or medications known to have effect on central nervous system

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Istituti Clinici Scientifici Maugeri SpA

Pavia, Ita, 27100, Italy

RECRUITING

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 7, 2023

First Posted

March 20, 2023

Study Start

May 24, 2021

Primary Completion (Estimated)

April 30, 2027

Study Completion (Estimated)

October 31, 2027

Last Updated

April 8, 2026

Record last verified: 2025-04

Locations