Neural Bases of Decision-making in Healthy Individuals

NCT05774834 | Recruiting

• 1 other identifier: 2137
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this single center non-interventional fMRI study is to assess the neural bases of decision-making and executive functioning in healthy individuals,and whether/how their responsiveness is modulated by ageing. The main questions it aims to answer are:

1. 1.are there specific neural correlates for ageing effects on executive functioning (particularly inhibitory control) and decision-making?
2. 2.Is there a relationship, at the behavioral and neural levels, between ageing-related changes in executive functioning and decision-making?
3. 3.a behavioral assessment including multiple tests of decision-making and executive functioning/inhibitory control;
4. 4.a fMRI session to collect data concerning a) brain activity associated with decision-making and executive functioning, b) brain structural morphometriy (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging).

Conditions

Healthy Volunteers

Keywords

decision-making; executive functioning; fMRI; ageing

Outcome Measures

Primary Outcomes (1)

• Behavioral performance 1: Decision-making skills

  Participants' decision-making performance will be assessed in terms of "loss aversion" (i.e., the overweighting of potential losses compared with gains), after removing the potential confounding effect of risk aversion

  MRI-acquisition day 1

Secondary Outcomes (3)

• Behavioral performance 2: Executive functioning skills

  MRI-acquisition day 1

• Brain activity underlying decision-making and executive performance

  MRI-acquisition day 1

• Brain structure related to decision-making and executive performance

  MRI-acquisition day 1

Study Arms (1)

All healthy participants

All healthy participants will undergo behavioral assessment and fMRI

Other: No intervention

Interventions

No intervention OTHER

No intervention

All healthy participants

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

150 healty individuals, aged 18-60 years, sampled from the general population

You may qualify if:

• Healthy participants, as determined by screening assessments and principal investigator judgment
• The participant must be able to comply with study requirements as judged by the principal investigator

You may not qualify if:

• Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse
• Use of any psychoactive medication, or medications known to have effect on central nervous system (CNS) or blood flow
• Any contraindications for magnetic resonance imaging (MRI) scans or any brain/head abnormalities restricting MRI eligibility

Sponsors & Collaborators

• Istituto Universitario di Studi Superiori Pavia: collaborator
• Istituti Clinici Scientifici Maugeri SpA: lead

Study Sites (1)

Istituti Clinici Scientifici Maugeri SpA

Pavia, Ita, 27100, Italy

RECRUITING

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2023
• First Posted: March 20, 2023
• Study Start: November 10, 2018
• Primary Completion (Estimated): April 30, 2027
• Study Completion (Estimated): October 31, 2027
• Last Updated: April 8, 2026

Record last verified: 2025-04

Locations

IT (1)