Wastewater Surveillance to Boost COVID-19 Vaccine Uptake

NCT05766189 | Completed

• 1 other identifier: BOOST-wastewater
• Study Type: interventional
• Target: 100,000
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of the study is to determine the effect of a communications campaign sharing wastewater surveillance data to influence vaccine uptake in a metropolitan and non-metropolitan environment. The study will be conducted in Onondaga and Cayuga counties in New York State. Individuals of all ages within the selected counties, located in metropolitan and non-metropolitan environments will receive the intervention. The evaluation study design is a comparison-control trial. The primary outcome measure is the proportion of vaccine-eligible individuals in the county that received the COVID-19 vaccine stratified by type of vaccine dosage and age group. Vaccination data will be aggregated to the county by the State Department of Health and shared with the research team. Wastewater data will be pulled from the wastewater surveillance network. A difference in differences analysis will be used to estimate the effect of the intervention on both the outcomes between intervention and comparison groups following the intervention, while adjusting for potential confounding factors.

Conditions

Vaccination; Wastewater Surveillance

Outcome Measures

Primary Outcomes (1)

• Vaccine uptake

  Number of individuals receiving a booster COVID-19 vaccine

  up to 3 months

Study Arms (2)

Intervention arm

EXPERIMENTAL

Receives communications on level of SARS-CoV-2 as identified in the wastewater

Behavioral: Wastewater vaccine prompts

Comparison arm

NO INTERVENTION

Interventions

Wastewater vaccine prompts BEHAVIORAL

Social media communications showing levels of SARS-CoV-2 in wastewater

Intervention arm

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• None - county-level vaccine uptake - no direct interaction with people getting vaccines

You may not qualify if:

• None

Sponsors & Collaborators

• Syracuse University: lead

Study Sites (1)

Syracuse University

Syracuse, New York, 13244, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Difference-in-differences

Study Record Dates

• First Submitted: February 15, 2023
• First Posted: March 13, 2023
• Study Start: March 1, 2023
• Primary Completion: July 31, 2025
• Study Completion: December 31, 2025
• Last Updated: January 14, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)