Uterine Junctional Zone and Its Relation to Adverse Obstetrical Outcomes in Assisted Reproductive Technology
Uterine Junctional Zone Evaluation on 3D Ultrasound and Its Relation to Major Adverse Obstetrical Outcomes in Assisted Reproductive Technology
1 other identifier
observational
200
1 country
3
Brief Summary
The junctional zone (JZ) is an internal layer of the myometrium, with unique characteristics that allow its visualization as a hypoechogenic structure in three-dimensional (3D) ultrasound. While there is a growing realization that the origins of major obstetrical complications associated with defective deep placentation, such as pre-term labour, fetal growth restriction and pre-eclampsia, may lie in the very early pregnancy events, the underlying mechanisms are not understood.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2023
Typical duration for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 24, 2023
CompletedFirst Submitted
Initial submission to the registry
February 27, 2023
CompletedFirst Posted
Study publicly available on registry
March 10, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2025
CompletedAugust 20, 2024
August 1, 2024
2 years
February 27, 2023
August 19, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Pre-eclampsia
Pre-eclampsia rate
40 weeks
pre-term labour
pre-term labour rate
37 weeks
Fetal growth restriction
Fetal growth restriction rate
40 weeks
Secondary Outcomes (1)
High-risk first trimester screening for pre-eclampsia
12 weeks
Eligibility Criteria
Women included are followed in the fertility clinic aged between 18 and 40 years in cycles of IVF, ICSI or endometrial preparation for frozen embryo transfer
You may qualify if:
- Women followed in the infertility clinic aged between 18 and 42 years in cycles of IVF, ICSI or endometrial preparation for frozen embryo transfer
You may not qualify if:
- Myomas
- adenomyosis
- endometriosis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Hospital Central do Funchal
Funchal, Madeira, 9000, Portugal
Departamento de Obstetricia, Ginecologia e Medicina da Reprodução
Lisbon, 1600, Portugal
Centro Hospitalar Universitário Lisboa Norte
Lisbon, Portugal
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Isabel B Pereira, M.D
Centro Hospitalar Lisboa Norte
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- M.D.
Study Record Dates
First Submitted
February 27, 2023
First Posted
March 10, 2023
Study Start
February 24, 2023
Primary Completion
February 28, 2025
Study Completion
July 31, 2025
Last Updated
August 20, 2024
Record last verified: 2024-08