Acute Effects of Autoregulated and Non-autoregulated Blood Flow Restrictive Bicep Curls
1 other identifier
interventional
20
1 country
1
Brief Summary
The purpose of this study is to investigate the acute effects of autoregulated (AR) and non-autoregulated (NAR) blood flow restriction (BFR) bicep curls on indices of arterial stiffness. We are attempting to differentiate physiological changes with AR and NAR bicep curl exercise. Twenty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), AR BFR and NAR BFR) in a randomized order separated by one week. A familiarization session will also occur one week before starting the treatment period. Each subject will undergo a series of tests including anthropometry, ultrasonography of the carotid artery, applanation tonometry, ultrasonography of the vastus lateralis, blood pressure acquisition, body composition, and maximal strength assessments (1RM). After a familiarization session with the BFR device, subjects will perform arm curls during the three treatment sessions with 4 sets to failure with a 2 seconds concentric and 2 seconds eccentric cadence, at 20% 1RM using 60% of the supine limb occlusion pressure (LOP) with 1-minute rest intervals. Assessments will be performed immediately before and after the exercise bout during each treatment session. Two-way ANOVAs will be used to examine the effects of treatment and the treatment-order interaction on pulse wave velocity, beta-stiffness index, and augmentation index.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2023
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 8, 2023
CompletedFirst Posted
Study publicly available on registry
March 1, 2023
CompletedStudy Start
First participant enrolled
April 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 20, 2023
CompletedJuly 27, 2023
July 1, 2023
8 months
February 8, 2023
July 24, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
Beta-Stiffness Index
A measurement that compares carotid SBP and DBP with carotid systolic and diastole diameters.
10 minutes after exercise trial.
Carotid-femoral pulse wave velocity
A measurement that records the time difference between the foot of the systolic wave form as it arrives at the carotid and femoral arterial sites. It is measured with an arterial tonometer.
15 minutes after exercise trial.
Study Arms (3)
Autoregulated blood flow restriction
ACTIVE COMPARATORAutoregulated BFR expands as the muscle progresses into the stretch-shortening cycle.
Non-autoregulated blood flow restriction
ACTIVE COMPARATORNon-autoregulated BFR does not expand as the muscle progresses into the stretch-shortening cycle.
No blood flow restriction
ACTIVE COMPARATORThis group serves as the control group for this study
Interventions
Measure within \& between differences in acute vascular compliance from pre- to post-training with autoregulated BFR, nonautoregulated BFR and no BFR conditions.
Eligibility Criteria
You may qualify if:
- Age 18-40 years old
- Physically active (\> 6 months of consistent exercise training)
- Weight stable for previous 6 months (+/-2.5 kg)
- Female subjects only- reported regular menstrual cycles for the last 2 years
You may not qualify if:
- BP\>140/90 mmHg
- BMI\>40 kg/m2
- Diabetes
- Familial hypercholesterolemia
- Past or current history of CHD, stroke or major CVD events. Respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject.
- Women must not be pregnant, plan to become pregnant during the study, or be nursing
- Active renal or liver disease
- All medications and supplements that influence dependent variables
- Recent surgery \< 2 months
- Alcohol abuse
- Sleep apnea
- Claustrophobia
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Salisbury University
Salisbury, Maryland, 21801, United States
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
February 8, 2023
First Posted
March 1, 2023
Study Start
April 1, 2023
Primary Completion
December 1, 2023
Study Completion
December 20, 2023
Last Updated
July 27, 2023
Record last verified: 2023-07