Pilot Implementation of HIV Self-testing Delivery in Private Pharmacies Combined to a Respondent Driven Sampling Method to Improve HIV Testing for MSM and TGW in Phnom Penh - ANRS 0100s

NCT05745168 | Not Yet Recruiting DMC

• 1 other identifier: ANRS0100s
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to evaluate the feasibility of HIV self-testing (HIVST) delivery by a private pharmacy network among men who have sex with men (MSM) and transgender women (TGW) recruited through a classic and digital Respondent Driven Sampling method to improve HIV testing in Phnom Penh, Cambodia. An interventional pilot study using a mixed qualitative and quantitative approach will be carried out in order to evaluate the feasibility, acceptability and appropriateness of the strategy and to identify barriers and facilitators.

Conditions

HIV Infections

Keywords

Self-testing; Private pharmacy; RDS; MSM; Transgender women

Outcome Measures

Primary Outcomes (1)

• Acceptability proportion of HIV self-test by MSM/TGW provided by private pharmacy

  Number of HIV self-tests delivered / total number of coupons distributed

  February 2023 to April 2025

Secondary Outcomes (1)

• Acceptability and appropriateness provision of HIV self-test to MSM/TGW via private pharmacy

  February 2023 to April 2025

Study Arms (1)

MSM-TGW

Diagnostic Test: OraQuick

Interventions

OraQuick DIAGNOSTIC_TEST

The intervention is based on respondent-driven sampling approach. Each selected seed from hotspots and on social networks is provided with two types of coupons for HIVST kit at partner pharmacy: electronic coupons (e-coupons) consisting of a pictured unique anonymous QR code and identifier and the address of pharmacies; paper coupons consisting of similar information to e-coupon. The seeds will then distribute coupons to their networks physically, via social media, and smart phone applications. Each recruited participant will bring the coupon to be scanned at the pharmacies to receive a free access HIVST kit. There, trained community worker will do the study visit including information/consent, e-CRF filling and providing link to send the test results. These recruited individuals will be considered as wave 1 and will each receive 10 additional coupons to recruit new members in the networks. The next round of individuals recruited and enrolled will be considered as wave 2, and so on.

MSM-TGW

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: For MSM, to have at least one oral or anal intercourse with another man in the past 12 months; For TGW, to be biologically a male at birth and self-identified as a woman or third gender and have at least one oral, anal or vaginal intercourse with another man in the past 12 months
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The survey population consists of MSM and TGW aged from 18 years old who are living in Phnom Penh at the study period regardless of their nationalities or migration history (moving from other provinces)

You may qualify if:

• To be aged from 18 years old (legal age in Cambodia)
• For MSM, to have at least one oral or anal intercourse with another man in the past 12 months
• For TGW, to be biologically a male at birth and self-identified as a woman or third gender and have at least one oral, anal or vaginal intercourse with another man in the past 12 months

You may not qualify if:

• Known HIV positive status

Sponsors & Collaborators

• ANRS, Emerging Infectious Diseases: lead
• Saglik Bilimleri Universitesi: collaborator
• Sciences économiques et sociales de la santé et traitement de l'information médicale Marseille France: collaborator
• National Center For HIV/AIDS, DERMATOLOGY AND STD Phnom Penh, Cambodia: collaborator
• Institut de Recherche pour le Developpement: collaborator

Study Sites (1)

University of Health Sciences

Phnom Penh, 120210, Cambodia

Location

Related Publications (1)

• Dary C, Segeral O, Larmarange J, Mosnier E, Ben Mechlia M, Ouk V, Spire B, Saphonn V. Pilot Implementation of HIV Self-Testing Delivery in Private Pharmacies Combined With a Respondent-Driven Sampling Method to Improve HIV Testing for Men Who Have Sex With Men and Transgender Women in Phnom Penh (ANRS 0100s): Protocol for a Prospective Mixed Method Feasibility Study. JMIR Res Protoc. 2025 Jun 27;14:e65351. doi: 10.2196/65351.

  PMID: 40577719 DERIVED

MeSH Terms

Conditions

HIV Infections

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Study Officials

• Vonthanak Saphonn, PhD

  Saglik Bilimleri Universitesi

  PRINCIPAL INVESTIGATOR

• Mohamed Ben-Mechlia, PhD

  ANRS, Emerging Infectious Diseases

  STUDY DIRECTOR

• Bruno Spire, PhD

  SESSTIMS

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chhavarath Dary, PhD

CONTACT

85517676953; dr_chhavarath@uhs.edu.kh

Chhavarath Dary, PhD

CONTACT

3317676953; dr_chhavarath@uhs.edu.kh

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 16, 2023
• First Posted: February 27, 2023
• Study Start: June 1, 2024
• Primary Completion: April 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: January 30, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)