NCT05742542

Brief Summary

Maximal oxygen uptake (VO2max) is used to define cardiorespiratory fitness, which is important to health and sport performance in humans. Although different types of training can improve VO2max, the high intensity interval training is recognized as one of the best ways to do it. Furthermore, it has long been speculated that high intensity interval training that elicits a high time spent near VO2max could be the best way to improve VO2max. However, this theory has not been verified. Thus, the investigators performed a randomized controlled trial with crossover in healthy individuals who underwent two high intensity interval training protocols of two weeks, being a workout with longer and other with shorter time spent near VO2max.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
15

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2021

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 15, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2021

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

February 3, 2023

Completed
21 days until next milestone

First Posted

Study publicly available on registry

February 24, 2023

Completed
Last Updated

February 24, 2023

Status Verified

February 1, 2023

Enrollment Period

6 months

First QC Date

February 3, 2023

Last Update Submit

February 14, 2023

Conditions

Keywords

VO2maxExerciseAerobicPerformanceTraining

Outcome Measures

Primary Outcomes (1)

  • Maximal oxygen uptake

    The highest 15 seconds VO2 average determined from rolling averages of 5 seconds samples measured during incremental test or confirmation test of VO2max.

    Change at Maximal oxygen uptake after two weeks

Secondary Outcomes (6)

  • Lactate threshold

    Change at Lactate threshold after two weeks

  • Muscle oxidative capacity

    Change at Muscle oxidative capacity after two weeks

  • Pulmonary oxygen uptake kinetics

    Change at Pulmonary oxygen uptake kinetics after two weeks

  • Power output achieved at the end of incremental test

    Change at Power output achieved at the end of incremental test after two weeks

  • Wingate anaerobic test

    Change at Wingate anaerobic test after two weeks

  • +1 more secondary outcomes

Other Outcomes (5)

  • Session-rating of perceived exertion

    First to the last day of test or training, an average of 4 weeks

  • Perceived Recovery Status Scale

    First to the last day of test or training, an average of 4 weeks

  • Heart rate

    First to the last day of test or training, an average of 4 weeks

  • +2 more other outcomes

Study Arms (2)

High intensity interval training with high time spent near VO2max

EXPERIMENTAL

Participants performed high intensity interval training with high time spent near VO2max three times a week for two weeks. All training sessions consisted of five times 2 minutes of work and 1 minute of passive recovery. The work intensity was adjusted at 85% and 87% of power output achieved at the end of incremental test for the first and second week, respectively. The training sessions were performed using cycle ergometer. Findings were compared to high intensity interval training with low time spent near VO2max, which followed the same exercise frequency, intensity and total duration.

Other: Exercise training

High intensity interval training with low time spent near VO2max

EXPERIMENTAL

Participants performed high intensity interval training with low time spent near VO2max three times a week for two weeks. All training sessions consisted of ten times 1 minutes of work and 30 seconds of passive recovery. The work intensity was adjusted at 85% and 87% of power output achieved at the end of incremental test for the first and second week, respectively. The training sessions were performed using cycle ergometer. Findings were compared to high intensity interval training with high time spent near VO2max, which followed the same exercise frequency, intensity and total duration.

Other: Exercise training

Interventions

Two weeks of high intensity interval training with high or low time spent near VO2max.

High intensity interval training with high time spent near VO2maxHigh intensity interval training with low time spent near VO2max

Eligibility Criteria

Age18 Years+
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male ≥ 18 years;
  • No known musculoskeletal disorders;
  • Apparently healthy
  • Physically active according to American College of Sports Medicine standards and recommendations (Garber et al., 2011; RIEBE et al., 2015).

You may not qualify if:

  • Taking any medication that could affect aerobic parameters;
  • Smokers;
  • Involved in an aerobic training program at the start of the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of the State of Santa Catarina

Florianópolis, Santa Catarina, 88080-350, Brazil

Location

Related Publications (8)

  • Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle: Part I: cardiopulmonary emphasis. Sports Med. 2013 May;43(5):313-38. doi: 10.1007/s40279-013-0029-x.

    PMID: 23539308BACKGROUND
  • Laursen PB, Jenkins DG. The scientific basis for high-intensity interval training: optimising training programmes and maximising performance in highly trained endurance athletes. Sports Med. 2002;32(1):53-73. doi: 10.2165/00007256-200232010-00003.

    PMID: 11772161BACKGROUND
  • Lisboa FD, Raimundo JAG, Salvador AF, Pereira KL, Turnes T, Diefenthaeler F, Oliveira MFM, Caputo F. Acute Cardiopulmonary, Metabolic, and Neuromuscular Responses to Severe-Intensity Intermittent Exercises. J Strength Cond Res. 2019 Feb;33(2):408-416. doi: 10.1519/JSC.0000000000002130.

    PMID: 28704307BACKGROUND
  • Lisboa FD, Salvador AF, Raimundo JA, Pereira KL, de Aguiar RA, Caputo F. Decreasing Power Output Increases Aerobic Contribution During Low-Volume Severe-Intensity Intermittent Exercise. J Strength Cond Res. 2015 Sep;29(9):2434-40. doi: 10.1519/JSC.0000000000000914.

    PMID: 26308828BACKGROUND
  • Midgley AW, Mc Naughton LR. Time at or near VO2max during continuous and intermittent running. A review with special reference to considerations for the optimisation of training protocols to elicit the longest time at or near VO2max. J Sports Med Phys Fitness. 2006 Mar;46(1):1-14.

    PMID: 16596093BACKGROUND
  • Midgley AW, Mc Naughton LR, Wilkinson M. Criteria and other methodological considerations in the evaluation of time at V.O2max. J Sports Med Phys Fitness. 2006 Jun;46(2):183-8.

    PMID: 16823345BACKGROUND
  • Raimundo JAG, Turnes T, de Aguiar RA, Lisboa FD, Loch T, Ribeiro G, Caputo F. The Severe Exercise Domain Amplitude: A Comparison Between Endurance Runners and Cyclists. Res Q Exerc Sport. 2019 Mar;90(1):3-13. doi: 10.1080/02701367.2018.1549356. Epub 2019 Jan 17.

    PMID: 30653425BACKGROUND
  • Turnes T, de Aguiar RA, Cruz RS, Caputo F. Interval training in the boundaries of severe domain: effects on aerobic parameters. Eur J Appl Physiol. 2016 Jan;116(1):161-9. doi: 10.1007/s00421-015-3263-0. Epub 2015 Sep 15.

    PMID: 26373721BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • João G Raimundo, PhD

    Member of Human Performance Research Group

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
CROSSOVER
Model Details: The order of training protocols was randomized and the training programs had a washout period of at least one month.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Member of Human Performance Research Group

Study Record Dates

First Submitted

February 3, 2023

First Posted

February 24, 2023

Study Start

July 1, 2021

Primary Completion

December 15, 2021

Study Completion

December 15, 2021

Last Updated

February 24, 2023

Record last verified: 2023-02

Locations