NCT05738902

Brief Summary

The aim of the study is to investigate the association between early non-compliance to ERAS in postoperative day 2 (POD2) with the rate of postoperative complications.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
600

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2023

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 13, 2023

Completed
9 days until next milestone

First Posted

Study publicly available on registry

February 22, 2023

Completed
3 months until next milestone

Study Start

First participant enrolled

May 30, 2023

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2025

Completed
Last Updated

January 25, 2024

Status Verified

January 1, 2024

Enrollment Period

1.8 years

First QC Date

February 13, 2023

Last Update Submit

January 24, 2024

Conditions

Keywords

ERAS; gynecologic cancer;

Outcome Measures

Primary Outcomes (1)

  • Early non-compliance to ERAS

    Association between the early non-compliance to ERAS with the rate of postoperative complications.

    Postoperative day 2 (POD2)

Secondary Outcomes (1)

  • Early non-compliance to ERAS in tubo-ovarian cancer

    Postoperative day 2 (POD2)

Study Arms (1)

Women affected by gynecological cancer.

Women affected by confirmed gynecological cancer treated with open access surgery and managed according to ERAS guidelines.

Other: Assessment of compliance to ERAS.

Interventions

Assessment of compliance to ERAS in postoperative day 2 (POD2) using five indicators based on ERAS items and association with postoperative complications up to 30 days after discharge.

Women affected by gynecological cancer.

Eligibility Criteria

Age18 Years - 75 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Women affected by hystological confirmed gynecological cancer treated with open access surgery.

You may qualify if:

  • histological diagnosis of primary or recurrent gynecological cancer (endometrial, uterine, tubo-ovarian and cervical cancer);
  • perioperative management according to ERAS guidelines;
  • age 18-75;
  • open access surgery.

You may not qualify if:

  • postoperative recovery in intensive care unit (planned or unplanned);
  • Covid19 positive status known at the moment of surgery;
  • minimally invasive access surgery or palliative surgery;
  • prior pelvic radiotherapy;
  • hyperthermic intraperitoneal chemotherapy;
  • previous abdominal surgery (excluding appendectomy and primary surgery for gynecological malignancy);
  • pelvic exenteration or lateral extended endopelvic resection (LEER).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Federico Ferrari

Brescia, BS, 25123, Italy

RECRUITING

Related Publications (1)

  • Ferrari F, Bizzarri N, Fagotti A, Scambia G, Gozzini E, Soleymani Majd H, Rota M, Odicino F. Early non-compliance to ERAS in gynecological open surgery for malignancies, and post-operative complications: a multicenter, prospective, observational, cohort study. Int J Gynecol Cancer. 2025 Dec;35(12):101833. doi: 10.1136/ijgc-2024-005648. Epub 2025 Apr 17.

MeSH Terms

Conditions

Pain, PostoperativeOvarian NeoplasmsEndometrial NeoplasmsUterine Cervical NeoplasmsUterine NeoplasmsGenital Neoplasms, Female

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and SymptomsEndocrine Gland NeoplasmsNeoplasms by SiteNeoplasmsOvarian DiseasesAdnexal DiseasesGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesUrogenital NeoplasmsGenital DiseasesEndocrine System DiseasesGonadal DisordersUterine DiseasesUterine Cervical Diseases

Study Officials

  • Federico Ferrari, MD, PhD

    University of Brescia, Italy

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Federico Ferrari, MD, PhD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Consultant and Assistant Professor at Spedali Civili of Brescia and University of Brescia

Study Record Dates

First Submitted

February 13, 2023

First Posted

February 22, 2023

Study Start

May 30, 2023

Primary Completion

March 31, 2025

Study Completion

March 31, 2025

Last Updated

January 25, 2024

Record last verified: 2024-01

Data Sharing

IPD Sharing
Will not share

Locations