Turkish Speech Analysis Development Study

NCT05732519 | Active Not Recruiting

• 1 other identifier: AlzheimerSpeech
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this observational study is to define speech alterations in the diagnosis of AD-related minor neurocognitive disorder (m-NBB) and major neurocognitive disorder (M-NBB). It is the development of a speech analysis method that can be used in future studies or routine clinical evaluations in these patients by using artificial intelligence and speech recognition methods that are planned to be developed based on the findings obtained. Purposes of the research

1. 1.To define language disorders in the diagnosis of AD-related minor neurocognitive disorder (m-NBB) and major neurocognitive disorder (M-NBB).
2. 2.Developing a speech analysis method that can be used in the early diagnosis of neurocognitive disorder patients by using artificial intelligence and speech recognition methods, which are planned to be developed based on the findings.
3. 3.Evaluation of whether speech analysis distinguishes patients with m-NBB and M-NBB due to AD
4. 4.Evaluation of whether speech analysis distinguishes minor NBD patients from healthy elderly patients.

Conditions

Alzheimer Disease; Mild Cognitive Impairment

Keywords

Speech recognition; Alzheimer disease; Mild cognitive impairment; Neurocognitive disorder; linguistics

Outcome Measures

Primary Outcomes (1)

• Reaching the sufficient number of participants (120 patients and 60 healthy controls, 180 volunteers in total) and comparing the speech/language functions of the two patient groups with the healthy control group

  about a year

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

\- Patients aged 60 and over followed up with the diagnosis of Minor Neurocognitive Disorder due to AD/ formerly Mild Cognitive Impairment (MCI) and major neurocognitive disorder due to mild or moderate AD according to DSM-5 and healthy elderly volunteers will be included to study.

You may qualify if:

• Healthy elderly volunteers will be invited to the study by advertisement, who do not have any neurological or psychiatric disorders, who do not use drugs, substances or alcohol that may affect cognitive functions, who do not have sensory defects that prevent the application of the tests, who have an SMMT score of 25 and above, who are 60 years of age and older will be included.
• For all three groups, the criterion of having received at least 5 years of education will be sought.

You may not qualify if:

• Presence of additional neurological or psychiatric disease in patient groups, and sensory deficits that prevent the application of tests.
• Patients with advanced AD diagnosis will not be included in the study.
• In addition, patients with a HAM-D score above 7 will be excluded from the study, since depression is thought to affect neuropsychological test performances.

Sponsors & Collaborators

• mihrimah ozturk: lead
• Ankara University: collaborator

Study Sites (1)

Ankara university Faculty of medicine

Ankara, Cankaya, 06000, Turkey (Türkiye)

Location

Related Publications (4)

• De Looze C, Dehsarvi A, Crosby L, Vourdanou A, Coen RF, Lawlor BA, Reilly RB. Cognitive and Structural Correlates of Conversational Speech Timing in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease: Relevance for Early Detection Approaches. Front Aging Neurosci. 2021 Apr 27;13:637404. doi: 10.3389/fnagi.2021.637404. eCollection 2021.

  PMID: 33986656 BACKGROUND

• Fraser KC, Meltzer JA, Rudzicz F. Linguistic Features Identify Alzheimer's Disease in Narrative Speech. J Alzheimers Dis. 2016;49(2):407-22. doi: 10.3233/JAD-150520.

  PMID: 26484921 BACKGROUND

• Gosztolya, G., Balogh, R., Imre, N., Egas-Lopez, J. V., Hoffmann, I., Vincze, V., ... & Kálmán, J. (2021). Cross-lingual detection of mild cognitive impairment based on temporal parameters of spontaneous speech. Computer Speech & Language, 69, 101215.

  BACKGROUND

• Mueller KD, Van Hulle CA, Koscik RL, Jonaitis E, Peters CC, Betthauser TJ, Christian B, Chin N, Hermann BP, Johnson S. Amyloid beta associations with connected speech in cognitively unimpaired adults. Alzheimers Dement (Amst). 2021 May 27;13(1):e12203. doi: 10.1002/dad2.12203. eCollection 2021.

  PMID: 34095435 BACKGROUND

MeSH Terms

Conditions

Alzheimer Disease; Cognitive Dysfunction; Neurocognitive Disorders

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Mental Disorders; Cognition Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: January 30, 2023
• First Posted: February 17, 2023
• Study Start: March 1, 2023
• Primary Completion: December 16, 2024
• Study Completion: December 16, 2025
• Last Updated: May 3, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)