Pain Inhibitory Effects of Other Pain Induced by Mechanical Pressure Compared to Electrical Stimulation and Cold Water.

NCT05730127 | Completed

• 1 other identifier: MechCPM1
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The objective is to estimate the effects on pain thresholds of a painful mechanical stimulus on the upper trapezius compared to a painful electrical stimulus and a diffuse noxious stimulus using the cold water hand immersion test.

Conditions

Healthy

Keywords

Conditioned Pain Modulation; Manual Therapy; Physiotherapy; Physical therapy

Outcome Measures

Primary Outcomes (1)

• Change from Baseline in Tibialis Anterior Pressure Pain Threshold (PPT) to immediate post-conditioning stimulus

  PPTs will be assessed on the dominant side over the tibialis anterior muscle using a digital algometer (Wagner instruments, Greenwich, CT, USA). Participants will be instructed to say "stop" when the pressure sensation becomes painful. The average of 3 assessments on the tibialis anterior of the dominant side will be performed for analysis. The algometer pressure for assessment will be gradually increased at a rate of 1kg/second. Data will be collected in kg/cm2.

  At baseline and immediately after the conditioning stimulus

Study Arms (3)

Mechanical pressure stimulation

EXPERIMENTAL

Mechanical compression is applied with the thumb to the upper trapezius muscle on the non-dominant side at the midpoint between the acromion and C7. The intensity of this will be regulated by the pain it causes the patient, trying to ensure that it is at all times approximately 5/10 on the numerical pain rating scale (NPRS) with 0 being "no pain at all" and 10 being "the worst pain imaginable". The stimulation will be carried out for 2 minutes.

Other: Conditioning stimulus

Electrical stimulation

ACTIVE COMPARATOR

To perform this procedure a TENS will be used applying a biphasic current, since it is the most used and studied type of electrotherapy. A frequency of 100hz and a bandwidth of 150 will be used. The intensity will be increased and decreased with the patient's feeback in order to provoke a pain of approximately 5/10 in the NPRS. The stimulation will be performed for 2 minutes on the upper trapezius of the non-dominant side at the midpoint between acromion and C7.

Other: Conditioning stimulus

Cold pressor task

ACTIVE COMPARATOR

The non-dominant hand shall be placed in a bucket of cold water at 10.5° for 2 minutes.

Other: Conditioning stimulus

Interventions

Conditioning stimulus OTHER

Pain stimulus on non-dominant side

Cold pressor task; Electrical stimulation; Mechanical pressure stimulation

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• healthy male or female between 18 and 65 years
• Free of pain and with no history of chronic pain

You may not qualify if:

• Pregnant or having given birth within the last year

Sponsors & Collaborators

• Josue Fernandez Carnero: lead

Study Sites (1)

Universidad Rey Juan Carlos

Alcorcón, Madrid, 28047, Spain

Location

Study Officials

• Josué Fernández Carnero, PhD

  Universidad Rey Juan Carlos

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 6, 2023
• First Posted: February 15, 2023
• Study Start: February 15, 2023
• Primary Completion: April 17, 2023
• Study Completion: April 21, 2023
• Last Updated: May 12, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)