Change in Cardiorespiratory Fitness and Breast Cancer Incidence and Mortality

NCT05729451 | Completed

• 1 other identifier: Dnr 2015/1864-31/2
• Study Type: observational
• Target: 53,644
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this observational study is to investigate the association between mid-life changes in cardiorespiratory fitness and the risk of breast cancer incidence and mortality among Swedish women. The main questions to answer are: \- Are changes in cardiorespiratory fitness associated with the risk of being diagnosed or dying from/with breast cancer later in life? Participants performed at least two occupational health assessment tests, which consisted of a submaximal ergometer cycle test, measurement of body mass and height to calculate BMI, and a questionnaires on physical and life style habits.

Conditions

Cancer of Breast; Cardiorespiratory Fitness; Occupational Health

Keywords

Cancer, Cardiorespiratory Fitness, Physical activity,

Outcome Measures

Primary Outcomes (2)

• Incidence of breast cancer

  ICD 10, C50 Malignant neuroplasm of breast

  From last health assessment test until 31th of December 2019

• breast cancer specific mortality

  ICD 10, C50 Malignant neuroplasm of breast

  From last health assessment test until 31th of December 2019

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Only women will be included in the study
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study used data from the Health Profile Assessment (HPA) database managed by the HPI Health Profile Institute AB in Stockholm, Sweden. The HPAs, which include a questionnaire on physical activity, lifestyle, and perceived health, as well as body mass and height measurements and a submaximal cardiorespiratory fitness test, have been conducted since the 1970s and stored in a central database since 1990. Participation was optional and offered to employees at no cost through the occupational and health services contracted by HPI and HPI was responsible for the standardization and administration of the database. The HPI-database was coupled to the national death registry to obtain data on cancer incidence and mortality of the involved participants.

You may qualify if:

• Older than 18 years
• Performed at least two health assessment tests

You may not qualify if:

• Cancer diagnoses prior to the second health assessment test
• Missing data on any exposure or confounder

Sponsors & Collaborators

• The Swedish School of Sport and Health Sciences: lead
• HPI Health Profile Institute: collaborator
• Swedish Cancer Society: collaborator

MeSH Terms

Conditions

Breast Neoplasms; Neoplasms; Motor Activity

Condition Hierarchy (Ancestors)

Neoplasms by Site; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2023
• First Posted: February 15, 2023
• Study Start: January 1, 1990
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: February 15, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share