Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study

NCT05728801 | Unknown

• 1 other identifier: 2019.078
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive disorder (NCD) patients will be re-invited from our previous cohort (2013-2014) (N=488).

Conditions

Age-related Cognitive Decline; Cognitive Deterioration; Dementia, Mild

Keywords

Cognitive maintenance; Cognitive ageing; Superagers; Cognition; Quality of life; Brain health

Outcome Measures

Primary Outcomes (2)

• Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)

  The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.HK MoCA score less than 26 indicates cognitive impairments.

  2022-2024

• Complex attention will be measured by Attention Network Test (ANT)

  Attention Network Test (ANT). The ANT paradigm (Download from: https://www.sacklerinstitute.org/cornell/assays\_and\_tools/ant/jin.fan/), as a computerized test, was used and performed by E-Prime 3.0 (Psychology Software Tools, PA, USA). Within ANT paradigm, there are four types of cue: no cue, center cue, double cue, and spatial cue; and three types of flanker: neutral, congruent, and incongruent. In a given trial, a central cross-fixation point presents for 400 to 1,600 ms (randomized), subsequently is replaced for 100 ms by one of four warning cues. The target, a central arrow could appear above or below the cross-fixation and is surrounded by two flankers on each side.

  2022-2024

Secondary Outcomes (1)

• Learning and memory will be measured by Word list learning test (WLLT)

  2022-2024

Study Arms (3)

Superagers

SuperAgers are determined by the scores of global cognitive function. This ensured that the participants are divided by a measure relevant to the current study without directly biasing the results toward the domain of interest.

Diagnostic Test: Ageing

Normal ageing elderly

The cases with the scores of cognitive performance within 1.5 standard deviation (SD) of age and education matched normative values derived from our cohort study, of which presented with HK MoCA score greater than 26 and CDR score equal to 0

Diagnostic Test: Ageing

Neurocognitive disorders patients

NCD patients are defined as: evidence of modest decline in one or more cognitive domains, which is set as ≥ 1.5 SD below the age- and education-adjusted normative scores; no interference with independence in everyday activities; and no comorbid major psychiatric disorders.

Diagnostic Test: Ageing

Interventions

Ageing DIAGNOSTIC_TEST

Using comprehensive cognitive tests to quality the domain-specific cognitive changes during ageing.

Neurocognitive disorders patients; Normal ageing elderly; Superagers

Eligibility Criteria

• Age: 60 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

High-performing elderly (SuperAgers) and the cases with normal ageing and neurocognitive disorder (NCD) will be re-invited in this study.

You may qualify if:

• SuperAgers are determined by the scores of global cognitive function. This ensured that the participants are divided by a measure relevant to the current study without directly biasing the results toward the domain of interest;
• Normal aging: the cases with the scores of cognitive performance within 1.5 standard deviation (SD) of age and education matched normative values derived from our cohort study, of which presented with HK MoCA score greater than 26 and CDR score equal to 0;
• NCD patients are defined as: evidence of modest decline in one or more cognitive domains, which is set as ≥ 1.5 SD below the age- and education-adjusted normative scores; no interference with independence in everyday activities; and no comorbid major psychiatric disorders.

You may not qualify if:

• History of bipolar disorders or psychosis;
• History of major neurological deficits including stroke, transient ischemic attack or traumatic brain injury;
• Comorbidities with depressive symptoms.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Tai Po Hospital

Hong Kong, Hong Kong

RECRUITING

Related Links

• Hong Kong SuperAgers

MeSH Terms

Conditions

Dementia; Lymphoma, Follicular

Interventions

Aging

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Intervention Hierarchy (Ancestors)

Growth and Development; Physiological Phenomena

Study Officials

• Hanna LU, PhD

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hanna LU, PhD

CONTACT

85226076063; hannalu@cuhk.edu.hk

Candy Wong

CONTACT

85226076063; candy.wong@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 6, 2023
• First Posted: February 15, 2023
• Study Start: June 1, 2022
• Primary Completion: June 1, 2024
• Study Completion: December 1, 2024
• Last Updated: December 12, 2023

Record last verified: 2023-12

Locations

HK (1)