Change in OHRQOL Following Minimally Invasive Treatment of Anterior Teeth in Children With MIH

NCT05727475 | Completed

• 1 other identifier: 556-2021
• Study Type: interventional
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

MIH is a prevalent developmental defect which has a negative impact on children's OHRQoL, especially when incisor opacities are present. The aim of this study is to evaluate the change in OHRQoL following minimally invasive aesthetic treatment of anterior permanent teeth opacities in children with MIH using the Arabic C-OHIP-SF19 as a data collection tool. This RCT will be conducted on children with MIH (n=156), aged 6-16 years, at the Post Graduate (PG) clinics, Jordan University of Science and Technology (Irbid). Patients will be randomly assigned in to two groups: Study group (n=78), with anterior teeth composite facing done to mask the opacity, and control group (n=78) where fluoride gel application was done. Children will be assessed by filling the COHIP-SF19 questionnaire before and one-month after the treatment to evaluate OHRQoL changes.

Conditions

Molar Incisor Hypomineralization

Keywords

Minimally invasive; Esthetic treatment; Oral health related quality of life; C-OHIP-SF19; Composite veneer

Outcome Measures

Primary Outcomes (1)

• OHRQoL changes

  Changes OHRQoL before and after the intervention and the difference between both groups (group 1 and 2).

  After 1 year

Study Arms (2)

Study group

ACTIVE COMPARATOR

In this group, a composite facing will be placed on the anterior incisors to mask the opacity. Minimal invasive treatment will be done without drilling or removal of enamel. They will be asked to fill in the Child Oral Health Impact Profile-Short Form (C-OHIP-SF19) questionnaire pre and 1 month post treatment.

Procedure: Minimal invasive restorative treatment

Control group

ACTIVE COMPARATOR

In this group, fluoride gel application will be done for all teeth using 1.23% APF gel delivered through a foam tray. They will be asked to fill in the Child Oral Health Impact Profile-Short Form (C-OHIP-SF19) questionnaire pre and 1 month post treatment. After filling the C-OHIP-SF19 questionnaire 1 month post treatment, if the child is not happy with the appearance after fluoride gel application, a composite facing will be offered.

Procedure: Fluoride gel application

Interventions

Minimal invasive restorative treatment PROCEDURE

Composite veneer facing without drilling or removal of enamel

Study group

Fluoride gel application PROCEDURE

Fluoride gel application 1.23%

Control group

Eligibility Criteria

• Age: 6 Years - 16 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Children with MIH and who have a visible enamel opacity involving at least one anterior permanent tooth;
• Children who request improvement in their anterior permanent teeth aesthetics.

You may not qualify if:

• Children who have an acute dental symptom and require urgent treatment;
• Children who need to undergo active treatment for their hypomineralized molars during the proposed study period (e.g., extractions) or orthodontic treatment;
• Children with any dental or facial anomaly other than MIH;
• Children with compromised incisor aesthetics due to a traumatic dental injury (crown fracture), tooth surface loss, or caries;
• Children with MIH and who do not have a visible enamel opacity involving at least one anterior permanent tooth; and
• Children with poor behavior.

Sponsors & Collaborators

• King Abdullah University Hospital: lead
• Jordan University of Science and Technology: collaborator

Study Sites (1)

Jordan University of Science and Technology

Irbid, 22110, Jordan

Location

Related Publications (13)

• Americano GC, Jacobsen PE, Soviero VM, Haubek D. A systematic review on the association between molar incisor hypomineralization and dental caries. Int J Paediatr Dent. 2017 Jan;27(1):11-21. doi: 10.1111/ipd.12233. Epub 2016 Apr 21.

  PMID: 27098755 BACKGROUND

• Arheiam AA, Baker SR, Ballo L, Elareibi I, Fakron S, Harris RV. The development and psychometric properties of the Arabic version of the child oral health impact profile-short form (COHIP- SF 19). Health Qual Life Outcomes. 2017 Nov 13;15(1):218. doi: 10.1186/s12955-017-0796-4.

  PMID: 29132377 BACKGROUND

• Broder HL, Wilson-Genderson M, Sischo L. Reliability and validity testing for the Child Oral Health Impact Profile-Reduced (COHIP-SF 19). J Public Health Dent. 2012 Fall;72(4):302-12. doi: 10.1111/j.1752-7325.2012.00338.x. Epub 2012 Apr 27.

  PMID: 22536873 BACKGROUND

• da Costa-Silva CM, Jeremias F, de Souza JF, Cordeiro Rde C, Santos-Pinto L, Zuanon AC. Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paediatr Dent. 2010 Nov;20(6):426-34. doi: 10.1111/j.1365-263X.2010.01097.x. Epub 2010 Aug 24.

  PMID: 20738434 BACKGROUND

• Hasmun N, Lawson J, Vettore MV, Elcock C, Zaitoun H, Rodd H. Change in Oral Health-Related Quality of Life Following Minimally Invasive Aesthetic Treatment for Children with Molar Incisor Hypomineralisation: A Prospective Study. Dent J (Basel). 2018 Nov 1;6(4):61. doi: 10.3390/dj6040061.

  PMID: 30388743 BACKGROUND

• Hasmun N, Vettore MV, Lawson JA, Elcock C, Zaitoun H, Rodd HD. Determinants of children's oral health-related quality of life following aesthetic treatment of enamel opacities. J Dent. 2020 Jul;98:103372. doi: 10.1016/j.jdent.2020.103372. Epub 2020 May 11.

  PMID: 32437856 BACKGROUND

• Minamidate T, Haruyama N, Takahashi I. The development, validation, and psychometric properties of the Japanese version of the Child Oral Health Impact Profile-Short Form 19 (COHIP-SF 19) for school-age children. Health Qual Life Outcomes. 2020 Jul 11;18(1):224. doi: 10.1186/s12955-020-01469-y.

  PMID: 32653004 BACKGROUND

• Oyedele TA, Folayan MO, Adekoya-Sofowora CA, Oziegbe EO. Co-morbidities associated with molar-incisor hypomineralisation in 8 to 16 year old pupils in Ile-Ife, Nigeria. BMC Oral Health. 2015 Mar 13;15:37. doi: 10.1186/s12903-015-0017-7.

  PMID: 25887347 BACKGROUND

• Schwendicke F, Elhennawy K, Reda S, Bekes K, Manton DJ, Krois J. Global burden of molar incisor hypomineralization. J Dent. 2018 Jan;68:10-18. doi: 10.1016/j.jdent.2017.12.002. Epub 2017 Dec 6.

  PMID: 29221956 BACKGROUND

• Sischo L, Broder HL. Oral health-related quality of life: what, why, how, and future implications. J Dent Res. 2011 Nov;90(11):1264-70. doi: 10.1177/0022034511399918. Epub 2011 Mar 21.

  PMID: 21422477 BACKGROUND

• Weerheijm KL, Duggal M, Mejare I, Papagiannoulis L, Koch G, Martens LC, Hallonsten AL. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent. 2003 Sep;4(3):110-3.

  PMID: 14529329 BACKGROUND

• William V, Messer LB, Burrow MF. Molar incisor hypomineralization: review and recommendations for clinical management. Pediatr Dent. 2006 May-Jun;28(3):224-32.

  PMID: 16805354 BACKGROUND

• Zawaideh FI, Al-Jundi SH, Al-Jaljoli MH. Molar incisor hypomineralisation: prevalence in Jordanian children and clinical characteristics. Eur Arch Paediatr Dent. 2011 Feb;12(1):31-6. doi: 10.1007/BF03262776.

  PMID: 21299943 BACKGROUND

MeSH Terms

Conditions

Molar Hypomineralization

Condition Hierarchy (Ancestors)

Dental Enamel Hypomineralization; Developmental Defects of Enamel; Tooth Abnormalities; Stomatognathic System Abnormalities; Stomatognathic Diseases; Tooth Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Ola B. Al-Batayneh

  Jordan University of Science and Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 5, 2023
• First Posted: February 14, 2023
• Study Start: November 12, 2021
• Primary Completion: June 1, 2023
• Study Completion: June 1, 2023
• Last Updated: November 14, 2023

Record last verified: 2023-11

Locations

JO (1)