Healthcare Disparities in Alopecia Areata

NCT05727306 | Completed Results

• 1 other identifier: p068
• Study Type: observational
• Target: 4,052,231
• Locations: 1 country
• Sites: 1

Brief Summary

Alopecia areata (AA) is a common immune-mediated non-scarring alopecia often associated with substantial morbidity. There are however, limited population-based data on potential disparities in the burden of AA, including across people of different ethnicities and deprivation. We aimed to provide the first large-scale, population-based estimate of lifetime risk of AA overall and by important sociodemographic subgroups. As AA is associated with an increased burden of mental health conditions and work-related outcomes (unemployment, time off work), a detailed understanding of the burden of disease in different sociodemographic groups is vital to plan resource provision.

Conditions

Alopecia Areata

Outcome Measures

Primary Outcomes (3)

• Likelihood of Depressive Episodes

  Estimated using logistic regression and reported using adjusted odds ratios

  Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant

• Likelihood of Recurrent Major Depressive Disorder

  Estimated using logistic regression and reported using adjusted odds ratios

  Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant

• Likelihood of Anxiety Disorder

  Estimated using logistic regression and reported using adjusted odds ratios

  Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant

Secondary Outcomes (5)

• Relative Incidence of Primary Care Attendances

  Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

• Relative Incidence of Dermatology Referrals

  Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

• Relative Incidence Psychological Therapy

  Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

• Relative Incidence of Unemployment

  Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

• Relative Incidence of Time Off Work

  Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

Study Arms (2)

People with Alopecia Areata

Children and adults aged 12+ with new onset Alopecia Areata registered with a contributing General practitioner (GP) practice during the study period.

Other: No intervention

People without Alopecia Areata

Children and adults aged 12+ without Alopecia Areata registered with a contributing GP practice during the study period.

Other: No intervention

Interventions

No intervention OTHER

Observational analysis of usual care only.

People with Alopecia Areata; People without Alopecia Areata

Eligibility Criteria

• Age: 12 Years - 95 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All individuals with new onset AA during the study period defined by the presence of at least one disease specific diagnostic code will be eligible for inlcusion in the AA cohort. Controls will be matched people without AA matched on age, sex, geography, ethnicity, socioeconomic status.

You may qualify if:

• Patients aged greater than 12 over the study period.
• Registered with the contributing primary care practice for any duration during the study period

You may not qualify if:

• People diagnosed with AA before the study period.

Sponsors & Collaborators

• Momentum Data: lead
• Pfizer: collaborator
• University of Oxford: collaborator

Study Sites (1)

Momentum Data Limited

London, United Kingdom

Location

MeSH Terms

Conditions

Alopecia Areata

Condition Hierarchy (Ancestors)

Alopecia; Hypotrichosis; Hair Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Results Point of Contact

• Title: Andrew G. Messenger
• Organization: University of Sheffield

a.g.messenger@sheffield.ac.uk

+44 114 222 2000

Study Officials

• Andrew McGovern, MD

  Momentum Data

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 11, 2023
• First Posted: February 14, 2023
• Study Start: October 1, 2022
• Primary Completion: July 24, 2024
• Study Completion: August 6, 2024
• Last Updated: June 18, 2025
• Results First Posted: June 18, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: SAP
• Time Frame: There is no pre-specified time-frame for data availability; this will be considered on an individual basis for each request.
• Access Criteria: As above.

Locations

GB (1)