Carnosine Supplementation and Cardiovascular Function

NCT05723939 | Unknown

• 1 other identifier: ZCICarnosine
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high concentrations in the brain, heart, and gastrointestinal tissues of humans. Although its physiological role has not been completely understood yet, carnosine is a non-enzymatic free-radical scavenger and a natural antioxidant and has anti-inflammatory and neuroprotective properties. The hypothesis of this research is that the consumption of carnosine supplements in the form of capsules, as well as chicken meat enriched with carnosine (functional food) has a beneficial effect on vascular reactivity measured in different vascular basins, and the lipid profile with a positive effect on the reduction of oxidative stress and inflammatory response in healthy sedentary people. subjects and active athletes measured in different vascular basins. The main goal of this study is to investigate the influence of carnosine supplement consumption (in the form of capsules and functional food) on vascular and endothelial function in a population of healthy young subjects and active athletes.

Conditions

Carnosine

Keywords

carnosine; oxidative stress; vascular reactivity; endothelium; inflammation; microcirculation; macrocirculation

Outcome Measures

Primary Outcomes (3)

• Microvascular endothelial function

  Cutaneous microvascular blood flow will be measured by Laser Doppler Flowmetry in response to vascular occlusion (post occlusive reactive hyperaemia - PORH), in response to iontophoresis of acetylcholine (ACh) and local thermal hyperemia (LTH).

  3 weeks

• Macrovascular endothelial function

  Measurement of flow mediated dilation (FMD) of brachial artery using ultrasound.

  3 weeks

• Cerebrovascular reactivity

  Measurement of cerebrovascular blood flow using transcranial color Doppler (TCD).

  3 weeks

Secondary Outcomes (10)

• Lipid profile

  3 weeks

• Oxidative stress status

  3 weeks

• Systemic hemodynamics

  3 weeks

• Serum Pro- and Anti-Inflammatory Cytokines, Chemokines, Growth Factors and Soluble Cell Adhesion Molecules Protein Concentration

  3 weeks

• Body composition

  3 weeks

Study Arms (2)

Carnosine

EXPERIMENTAL

Intake of carnosine supplement in form of capsules or functionally enriched chicken meet for three weeks

Dietary Supplement: Carnosine supplementation

Control

PLACEBO COMPARATOR

Intake of placebo capsules or regular chicken meet for three weeks

Dietary Supplement: Controls

Interventions

Carnosine supplementation DIETARY_SUPPLEMENT

Intake of carnosine supplement in form of capsules or functionally enriched chicken meet for three weeks

Carnosine

Controls DIETARY_SUPPLEMENT

Intake of placebo capsules or regular chicken meet for three weeks

Control

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• young healthy sedentary individuals - did not perform regular physical activities for at least 12 months before conducting the study
• young healthy active athletes - have a minimum of 5 training sessions per week (mainly endurance training) for at least 12 months prior to conducting the study

You may not qualify if:

• smoking
• hypertension
• coronary disease
• diabetes
• hyperlipidemia
• kidney damage
• cerebrovascular and peripheral artery diseases
• and any other disease that could have an impact on vascular and endothelial function

Sponsors & Collaborators

• Josip Juraj Strossmayer University of Osijek: lead

Study Sites (1)

Scientific Center of Excellence for Personalized Health Care, Josip Juraj Strossayer University of Osijek

Osijek, 31000, Croatia

RECRUITING

Related Publications (1)

• Peric L, Drenjancevic I, Jukic I, Boris A, Susnjara P, Kolobaric N, Mihaljevic Z, Kralik Z, Kralik G, Kosevic M, Galovic O, Stupin A. Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes-a randomized study. Appl Physiol Nutr Metab. 2025 Jan 1;50:1-11. doi: 10.1139/apnm-2024-0458.

  PMID: 39983097 DERIVED

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Ines Drenjančević, MD, PhD

CONTACT

+385-31-51-28-00; ines.drenjancevic@mefos.hr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: January 22, 2023
• First Posted: February 13, 2023
• Study Start: September 1, 2022
• Primary Completion: December 31, 2023
• Study Completion: June 30, 2024
• Last Updated: February 14, 2023

Record last verified: 2023-02

Locations

CR (1)