Physiological and Eating-behavioral Responses to Viewing Sensory-specific Food Pictures

NCT05719142 | Completed

• 1 other identifier: RM-110729522
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of the research project is to characterize the consequences of digital food stimuli exposure on eating behavior. Specifically, we aim to study cephalic phase physiology, food choice and quantity, as well as post-ingestive sensations in response to viewing sensory-specific food pictures. Furthermore, we want to examine whether these outcomes depend on sweet taste liking, as determined by FGF21 concentrations in the blood and the phenotypical Sweet Taste Liker Test. Section 2.1 lists the primary hypotheses.

Conditions

Food Preferences; Eating Behavior; Psychological

Outcome Measures

Primary Outcomes (1)

• Pancreatic polypeptide concentrations (pg/ml)

  Assessed from blood samples in fasted state. Mixed models repeated measures comparison with subsequent post hoc testing.

  Change against baseline (t = -15, 0 minutes) at t = 2, 4, 6, 8, 10, 15, 30 minutes, compared between visits (at least one week between each visit)

Secondary Outcomes (17)

• Hunger (self-reported, VAS)

  Baseline (t = -15, 0 minutes) vs. after picture viewing (t = 15 minutes) vs. after breakfast consumption (t = 45 minutes), between-visit differences in differences (at least one week between each visit)

• Desire to eat something (self-reported, VAS)

  Baseline (t = -15, 0 minutes) vs. after picture viewing (t = 15 minutes) vs. after breakfast consumption (t = 45 minutes), between-visit differences in differences (at least one week between each visit)

• Desire for something sweet (self-reported, VAS)

  Baseline (t = -15, 0 minutes) vs. after picture viewing (t = 15 minutes) vs. after breakfast consumption (t = 45 minutes), between-visit differences in differences (at least one week between each visit)

• Desire for something salty (self-reported, VAS)

  Baseline (t = -15, 0 minutes) vs. after picture viewing (t = 15 minutes) vs. after breakfast consumption (t = 45 minutes), between-visit differences in differences (at least one week between each visit)

• Desire for something fatty (self-reported, VAS)

  Baseline (t = -15, 0 minutes) vs. after picture viewing (t = 15 minutes) vs. after breakfast consumption (t = 45 minutes), between-visit differences in differences (at least one week between each visit)

Study Arms (3)

Sweet Food (SW)

EXPERIMENTAL

Exposure to pictures of sweet food.

Other: Picture exposure

Savoury Food (SA)

EXPERIMENTAL

Exposure to pictures of savoury food.

Other: Picture exposure

Non-Food (NF)

EXPERIMENTAL

Exposure to pictures of non-food items.

Other: Picture exposure

Interventions

Picture exposure OTHER

Participants are shown pictures for 15 minutes; 50 images in total, each shown for 6 seconds, and 3 times in total.

Non-Food (NF); Savoury Food (SA); Sweet Food (SW)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Normal or corrected-to-normal vision and no color-blindness
• Danish understanding

You may not qualify if:

• Regular smoking
• Dietary constraints, e.g., vegan/vegetarian, gluten or lactose intolerance, allergies
• For women: pregnancy / planned pregnancy (within the study period) / lactating
• Unable to understand the informed consent and the study procedures
• Self-reported history of an eating disorder in the past 3 years
• Uncontrolled medical issues, e.g.including, cardiovascular pulmonary, rheumatologic, hematologic, oncologic, infectious, GI or psychiatric disease, diabetes or other endocrine diseases, immunosuppression
• Current treatment with medication or medical devices significantly affecting glucose metabolism, appetite, or energy balance
• Current treatment with antidepressants
• Bariatric surgery

Sponsors & Collaborators

• Steno Diabetes Center Copenhagen: lead
• University of Aarhus: collaborator

Study Sites (1)

Steno Diabetes Center Copenhagen

Herlev, 2730, Denmark

Location

MeSH Terms

Conditions

Food Preferences; Feeding Behavior

Condition Hierarchy (Ancestors)

Behavior; Behavior, Animal

Study Officials

• Kristine Færch, PhD

  Steno Diabetes Center Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Participants will be aware of the study visit assignment during the study visit when exposed to the experimental stimuli, but not beforehand. Investigators will be aware also before the study visit.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All participants will complete all three study visits. The visits differ in the employed experimental stimuli, namely the pictures (sweet food, savoury food, non-food).

Study Record Dates

• First Submitted: January 19, 2023
• First Posted: February 8, 2023
• Study Start: January 17, 2023
• Primary Completion: June 29, 2023
• Study Completion: June 29, 2023
• Last Updated: August 15, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)