Collagen Cross-linking Clinical and Oct Study
Corneal Changes After Collagen Cross-linking ; Clinical and Oct Study
1 other identifier
observational
100
0 countries
N/A
Brief Summary
- 1.Assessment of corneal changes in AS-OCT after collagen cross-linking (corneal thickness and demarcation line).
- 2.Assessment of the effect of collagen cross-linking on best-corrected visual acuity
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2023
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 19, 2021
CompletedFirst Posted
Study publicly available on registry
February 8, 2023
CompletedStudy Start
First participant enrolled
August 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2024
CompletedJuly 19, 2023
July 1, 2023
7 months
October 19, 2021
July 18, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
corneal thickness after collagen cross linking OCT study
corneal thickness measurement in mm
12 months
Secondary Outcomes (1)
corneal demarcation line after collagen cross linking OCT study
12 months
Interventions
ant segment oct before and after corneal collagen cross-linking
Eligibility Criteria
patients who underwent classic corneal collagen cross-linking
You may qualify if:
- patients with e corneal ectasia who are candidates for CXL.
You may not qualify if:
- patients with other corneal diseases not treated by collagen cross-linking
- corneal scarring.
- previous corneal surgeries (e.g intrastromal corneal ring segments)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (4)
Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg. 2003 Sep;29(9):1780-5. doi: 10.1016/s0886-3350(03)00407-3.
PMID: 14522301BACKGROUNDRaiskup F, Spoerl E. Corneal crosslinking with riboflavin and ultraviolet A. I. Principles. Ocul Surf. 2013 Apr;11(2):65-74. doi: 10.1016/j.jtos.2013.01.002. Epub 2013 Jan 24.
PMID: 23583042BACKGROUNDBrummer G, Littlechild S, McCall S, Zhang Y, Conrad GW. The role of nonenzymatic glycation and carbonyls in collagen cross-linking for the treatment of keratoconus. Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6363-9. doi: 10.1167/iovs.11-7585.
PMID: 21724915BACKGROUNDRaiskup F, Terai N, Velika V, Sporl E. [Corneal Cross-Linking with Riboflavin and UVA in Keratoconus]. Klin Monbl Augenheilkd. 2016 Aug;233(8):938-44. doi: 10.1055/s-0042-102060. Epub 2016 Apr 7. German.
PMID: 27055493BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
mohammed saad, professor
CONTACT
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- resident doctor
Study Record Dates
First Submitted
October 19, 2021
First Posted
February 8, 2023
Study Start
August 1, 2023
Primary Completion
March 1, 2024
Study Completion
March 1, 2024
Last Updated
July 19, 2023
Record last verified: 2023-07