Circuit Training and Retina

NCT05714813 | Completed

• 1 other identifier: 20210271
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this research study is to see if high-speed weight training performed in a circuit (using one machine after another) can improve participant heart and brain function, strength, and power in older persons.

Conditions

Cognitive Impairment, Progressive; Cerebral Small Vessel Diseases

Keywords

Circuit Resistance Training; High-velocity Training; Retinal Microvasculature; Cognitive Function

Outcome Measures

Primary Outcomes (1)

• Change in retinal vessel density as measured by Optical Coherence Tomography Angiography (OCTA)

  OCTA uses a special camera system and software to measure the densities of the small vessels (microvasculature) of the retinal layers of the eye.

  Baseline, 24 weeks

Secondary Outcomes (12)

• Change in Event Memory as measured by the Picture Sequence Memory Test

  Baseline, 24 weeks

• Change in Information Sorting as measured by the NIH List Sorting Test

  Baseline, 24 weeks

• Change in Reaction Time for a Mental Task as measured by the NIH Pattern Comparison Processing Speed Test

  Baseline, 24 weeks

• Change in Dynamic Balance as measured by the Timed Up-and-Go test

  Baseline, 24 weeks

• Change in the Ability to perform Daily Activities as measured by the Physical Performance Test

  Baseline, 24 weeks

Study Arms (2)

High-Speed Circuit Resistance Training Group

EXPERIMENTAL

Participants in this group will receive high-speed circuit resistance training 3 times a week for 24 consecutive weeks for a total of 72 training sessions.

Behavioral: High-Speed Circuit Resistance Training

Control Group

OTHER

Participants in this arm will receive two lectures on fitness, diet, or cognition each month for 24 weeks for a total of 12 lectures.

Behavioral: Lecture on Diet, Exercise and Cognition

Interventions

High-Speed Circuit Resistance Training BEHAVIORAL

Performance of 24 weeks of high-speed concentric and low-speed eccentric lift across three circuits on eleven pneumatic machines. Each training session will be in person and will last between 45 minutes and one hour.

High-Speed Circuit Resistance Training Group

Lecture on Diet, Exercise and Cognition BEHAVIORAL

Lectures on diet, exercise, and cognition. Lectures will be provided in person or online and will last approximately one hour.

Control Group

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• years of age;
• Montreal Cognitive Assessment (MoCA) \> 23
• no memory loss complaints

You may not qualify if:

• Uncontrolled cardiovascular or neuromuscular diseases that prevent participation in a training program;
• Cerebrovascular disease;
• Malignancy within the previous 5 years;
• Documented HIV infection or other immunodeficiency syndrome;
• Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, or other serious concomitant medical illness;
• A history of ocular surgeries (except for cataract surgery more than 6 months ago) or other ocular diseases;
• Bilateral moderate or severe cataracts;
• Refractive errors of myopia, hyperopia and/or astigmatism more than 6.0 Diopters.

Sponsors & Collaborators

• University of Miami: lead

Study Sites (2)

Laboratory of Neuromuscular Research and Active Aging

Coral Gables, Florida, 33146-2416, United States

Location

Laboratory of Neuromuscular Research and Active Aging

Coral Gables, Florida, 33147, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Cerebral Small Vessel Diseases

Interventions

Exercise

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Joseph F Signorile, PhD

  University of Miami

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 21, 2022
• First Posted: February 6, 2023
• Study Start: September 1, 2021
• Primary Completion: September 30, 2022
• Study Completion: September 30, 2022
• Last Updated: February 6, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)