Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery

NCT05690867 | Completed

• 1 other identifier: 2021-2081
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Comparison of mechanical powers produced at volume controlled and pressure controlled mechanical ventilation

Conditions

Ventilator Lung

Keywords

mechanical power; volume controlled ventilation; pressure controlled ventilation

Outcome Measures

Primary Outcomes (1)

• calculation of mechanical power changes in two different ventilation modes

  mechanical power will be calculated using the Van der Meijden's formula for pressure support ventilation and Gattinoni's formula for volume controlled ventilation and two mechanical powers will be compared

  change from at the beginning of surgery till the end of surgery

Secondary Outcomes (2)

• postoperative pulmonary complications

  post-operative 7 days

• hospitalisation time

  up to 20 days

Study Arms (2)

Group 1

OTHER

group 1 starts with volume controlled ventilation

Other: Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes

Group 2

OTHER

group 2 starts with pressure controlled ventilation

Other: Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes

Interventions

Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes OTHER

group 1 starts with volume controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to pressure controlled ventilation after letting washout we take three consecutive measurements at pressure controlled ventilation and we will repeat this protocol during surgery

Group 1

Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes OTHER

group 2 starts with pressure controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to volume controlled ventilation after letting washout we take three consecutive measurements at volume controlled ventilation and we will repeat this protocol during surgery

Group 2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASA1-2 , \>18 years old patients having upper abdominal surgery

You may not qualify if:

• chronic obstructive lung disease, interstitial lung disease
• chronic renal failure
• Child-Pugh \> 6 liver disease
• Patients who don't give consent
• NYHA \> 2 heart failure

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Istanbul University, Department of Anesthesiology

Istanbul, 34093, Turkey (Türkiye)

Location

Related Publications (2)

• Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. The future of mechanical ventilation: lessons from the present and the past. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x.

  PMID: 28701178 BACKGROUND

• van der Meijden S, Molenaar M, Somhorst P, Schoe A. Calculating mechanical power for pressure-controlled ventilation. Intensive Care Med. 2019 Oct;45(10):1495-1497. doi: 10.1007/s00134-019-05698-8. Epub 2019 Jul 29. No abstract available.

  PMID: 31359082 BACKGROUND

Study Officials

• Istanbul University

  Istanbul University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 18, 2022
• First Posted: January 19, 2023
• Study Start: September 5, 2022
• Primary Completion: November 5, 2022
• Study Completion: December 5, 2022
• Last Updated: January 19, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)