Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery
NAVA vs Pressure Support After Cardiac Surgery, a Physiological Study
1 other identifier
interventional
12
1 country
1
Brief Summary
The study compares two different ventilation modes, Pressure support ventilation vs. Neuronally Adjusted Ventilatory Assist, in postcardiac surgery patients. Of special interest is shunt and alveolar deadspace and ventral vs. dorsal ventilation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2016
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 30, 2016
CompletedFirst Submitted
Initial submission to the registry
June 21, 2017
CompletedFirst Posted
Study publicly available on registry
July 14, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 2, 2025
CompletedApril 24, 2026
April 1, 2026
9.1 years
June 21, 2017
April 21, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Ventilation distribution
Redistribution of ventilation , dorsally vs. ventrally
Through study completion, within approximately 18 months
Alveolar dead space
Calculated from blood gases and end tidal pCO2,using standard formulae
Through study completion, within approximately 18 months
End expiratory lung impedance
Measured by Electric Impedance Tomography
Through study completion, within approximately 18 months
PaO2/FiO2
Arterial oxygenation
Through study completion, within approximately 18 months
Alveolar shunt
Calculated from mixed venous and arterial blood gases
Through study completion, within approximately 18 months
Study Arms (1)
NAVA vs Pressure Support
OTHERControl (pressure support) - NAVA - Control (Pressure Support) Intervention is NAVA
Interventions
Neurally Adjusted Ventilatory Assist is a fairly new ventilation mode
Eligibility Criteria
You may qualify if:
- Complicated Post Cardiac surgery patients in the ventilator weaning phase.
- Patients requiring assisted ventilation
- Respiratory and circulatory stable patients
- Sedated patients, RASS -2 to -3
You may not qualify if:
- Transplanted patients
- Pleural effusion.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Sahlgrenska University Hospital
Gothenburg, 41345, Sweden
Related Publications (1)
Martinsson A, Lundholm C, Ricksten SE, Oras J, Magnusson JM, Wallinder A, Sellgren J, Thoren A. Neurally adjusted ventilatory assist vs pressure support ventilation: short-term effects on shunt and dead space after cardiac surgery. Sci Rep. 2025 Dec 21;15(1):44234. doi: 10.1038/s41598-025-33097-1.
PMID: 41423634DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Anders Thoren, MD, PhD
University of Goteborg
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Masking Details
- The investigator works as physician at the Department of Intensive Care. The participants are patients.
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
June 21, 2017
First Posted
July 14, 2017
Study Start
August 30, 2016
Primary Completion
September 30, 2025
Study Completion
December 2, 2025
Last Updated
April 24, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share