NCT05688150

Brief Summary

This was a cross-sectional study. Patients who attended the osteoporosis clinic of Kowloon Hospital from June to December 2022 were recruited. Grip strength and appendicular skeletal muscle mass index were measured with a Jamar dynamometer and a bioimpedance analyser. Since most patients in our clinic are of Chinese ethnicity, the diagnostic criteria in the Consensus Update on Sarcopenia Diagnosis and Treatment by the Asian Working Group for Sarcopenia in 2019 was utilised. The diagnosis of sarcopenia was established by the presence of both low grip strength (Male: \< 28 kg, Female \< 18 kg) and low appendicular skeletal mass (Male: \< 7.0 kg/m2, Female: \< 5.7 kg/m2)

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
94

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jun 2022

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 20, 2022

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 12, 2022

Completed
9 days until next milestone

First Submitted

Initial submission to the registry

December 21, 2022

Completed
28 days until next milestone

First Posted

Study publicly available on registry

January 18, 2023

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2023

Completed
Last Updated

February 20, 2024

Status Verified

February 1, 2024

Enrollment Period

6 months

First QC Date

December 21, 2022

Last Update Submit

February 16, 2024

Conditions

SarcopeniaOsteoporosis

Keywords

osteosarcopeniasarcopeniaosteoporosisgeriatric medicine

Outcome Measures

Primary Outcomes (3)

  • Prevalence of Sarcopenia

    The diagnosis of sarcopenia would be established by the co-existence of low grip strength and low appendicular skeletal muscle mass.

    June - December 2022

  • Grip strength

    Grip strength would be measured with Jamar digital dynamometer.

    June - December 2022

  • Appendicular Skeletal Muscle Mass Index

    Appendicular Skeletal Muscle Mass Index would be measured with bioimpedance analyzer.

    June - December 2022

Secondary Outcomes (4)

  • Association between BMI and Sarcopenia.

    June - December 2022

  • Association between Frailty and Sarcopenia.

    June - December 2022

  • Association between Charlson Comorbidities Index and Sarcopenia

    June - December 2022

  • Association between Bone Mineral Densities and Sarcopenia

    June - December 2022

Eligibility Criteria

Age60 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients who attended the osteoporosis clinic of Kowloon Hospital from June to December 2022.

You may qualify if:

  • Patients aged 60 years old or above
  • Diagnosed with osteoporosis by: Fragility fracture or T-score ≤-2.5 SDs at any site on DXA scan and;
  • Able to read and write Chinese

You may not qualify if:

  • Unable to maintain standing posture for bioimpedance analysis
  • Modified Functional Ambulation Classification (MFAC) ≤ IV
  • Incompetent in giving consent
  • Unable to follow instructions
  • Implanted with metal in any of four limbs
  • Implanted with pacemaker, implantable cardioverter defibrillator or any other types of electrical device

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kowloon Hospital

Kowloon, Hong Kong

Location

Related Publications (1)

  • Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2. doi: 10.1016/j.jamda.2019.12.012. Epub 2020 Feb 4.

    PMID: 32033882BACKGROUND

MeSH Terms

Conditions

SarcopeniaOsteoporosis

Condition Hierarchy (Ancestors)

Muscular AtrophyNeuromuscular ManifestationsNeurologic ManifestationsNervous System DiseasesAtrophyPathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsSigns and SymptomsBone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 21, 2022

First Posted

January 18, 2023

Study Start

June 20, 2022

Primary Completion

December 12, 2022

Study Completion

February 28, 2023

Last Updated

February 20, 2024

Record last verified: 2024-02

Data Sharing

IPD Sharing
Will not share

Locations

HK(1)