NCT05679349

Brief Summary

This clinical trial tests how well providing education improves screening for lung cancer in patients with a history of smoking. Screenings may help doctors find lung cancer sooner when it may be easier to treat. Education and counseling may be an effective method to help providers and patients learn about lung cancer screening. Providing education and decision counseling to providers and patients may increase lung cancer screening.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
822

participants targeted

Target at P75+ for not_applicable

Timeline
9mo left

Started Apr 2024

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress74%
Apr 2024Feb 2027

First Submitted

Initial submission to the registry

December 23, 2022

Completed
19 days until next milestone

First Posted

Study publicly available on registry

January 11, 2023

Completed
1.2 years until next milestone

Study Start

First participant enrolled

April 1, 2024

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2027

Last Updated

May 6, 2026

Status Verified

May 1, 2026

Enrollment Period

2.8 years

First QC Date

December 23, 2022

Last Update Submit

May 1, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Completion of initial lung cancer screening (LCS)

    LCS will be assessed through an endpoint electronic medical records (EMR) search, supplemented with a question on the participant endpoint survey to capture any LCS performed outside the health system and/or not captured in the EMR.

    Within 4 months of randomization

Secondary Outcomes (4)

  • Referral for LCS

    Up to 5 years

  • Tobacco cessation services

    Up to 5 years

  • Repeat annual lung cancer screenings within 11-16 months of original screening

    within 11-16 months of original screening

  • Diagnostic follow up after initial lung cancer screening

    Up to 4 months of screening

Study Arms (4)

Group A (Providers): (survey, online educational activity)

EXPERIMENTAL

Participants complete survey on study. Participants undergo online educational activity on study. Participants undergo distance learning on study.

Other: Survey AdministrationOther: Educational Activity

Group B (Providers): (survey)

ACTIVE COMPARATOR

Participants complete survey at baseline and end of study survey.

Other: Survey Administration

Group A (Patients): (EHR, educational activity, counseling))

EXPERIMENTAL

Patients undergo EHR review on study. Patients undergo educational activity on study. Patients also undergo SDM counseling once on study.

Other: Electronic Health Record ReviewOther: Educational ActivityOther: Counseling

Group B (Patients): (survey)

ACTIVE COMPARATOR

Patients undergo EHR review on study and complete telephone survey throughout the trial.

Other: Survey AdministrationOther: Electronic Health Record Review

Interventions

Undergo online shared decision making training and distance learning

Group A (Providers): (survey, online educational activity)

Undergo shared decision making counseling

Also known as: Counseling Intervention
Group A (Patients): (EHR, educational activity, counseling))

Undergo electronic health record review

Group A (Patients): (EHR, educational activity, counseling))

Complete survey

Group A (Providers): (survey, online educational activity)

Eligibility Criteria

Age50 Years - 77 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • PRACTICE LEVEL:
  • Primary care practice (family medicine, geriatrics, internal medicine) in one of the 4 participating health systems
  • Practice using the main electronic medical record (EMR) of each system, in order to run appropriate patient recruitment reports
  • Practice with at least 50% of practice providers (physicians and advanced care providers) consenting to participate
  • PATIENT LEVEL:
  • Have an office or telemedicine established patient visit scheduled with a primary care provider in one of the participating practices within next 14 to 25 days
  • to 77 years of age
  • Have at least a 20-pack-year smoking history (based on self-report at baseline eligibility assessment)
  • Currently smoke or have quit smoking within the past 15 years (based on self-report at baseline eligibility assessment)
  • Able to communicate in English or Spanish (determined at baseline eligibility assessment)

You may not qualify if:

  • PATIENT OUTREACH:
  • Any lung computed tomography (CT) or low-dose computed tomography (LDCT) scan in the past 11 months, current procedural terminology (CPT) Codes are as follows
  • G0297 - LDCT screening
  • CT w/o contrast
  • CT w/ contrast
  • CT with and w/o contrast
  • CT angiography chest
  • Positron emission tomography computed tomography (PET CT) skull base to mid-thigh
  • PET CT whole body
  • Prior history of lung cancer (The patient's problem list includes a problem with an international classification of diseases (ICD10) code of "Z85.118" or one beginning with "C34.", or by self-report at baseline eligibility assessment)
  • Recent hospitalization (Admission date within the last 60 days listed in electronic health record (EHR), or by self-report at baseline eligibility assessment)
  • Dementia (diagnosis codes F03.90 or F03.91) in EHR

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sidney Kimmel Cancer Center at Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States

RECRUITING

MeSH Terms

Conditions

Lung Neoplasms

Interventions

Counseling

Condition Hierarchy (Ancestors)

Respiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Mental Health ServicesBehavioral Disciplines and ActivitiesCommunity Health ServicesHealth ServicesHealth Care Facilities Workforce and Services

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
SCREENING
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Professor - Medical Oncology

Study Record Dates

First Submitted

December 23, 2022

First Posted

January 11, 2023

Study Start

April 1, 2024

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

February 1, 2027

Last Updated

May 6, 2026

Record last verified: 2026-05

Locations