External Validation by Machine Learning and Reduction of the Input Dimensions of the D-PSY Scale for Dimensional Psychopathology

NCT05675215 | Unknown DMC

• 1 other identifier: 2022-A00076-37
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

There have been debates about whether psychiatric disorders should be classified according to categories (categorical model) or according to a continuum between normal and pathological functioning (dimensional model). While the former is the main one used to facilitate reliability, it has several limitations. We will use machine learning to develop a predictive model, bridging the gap between the dimensional and categorical approaches. Psychometric measures obtained from a questionnaire will be collected. Then, a supervised descriptor selection approach will be applied to predict categorical outcomes from dimensional inputs. The resulting prediction will be based on nonlinear modeling based on universal approximators. We developed this input questionnaire with four main objectives: 1) to briefly scan most of the categories generally described in the international nosography; 2) to use a continuous scale following a dimensional approach; 3) to use positively oriented sentences to decrease social desirability bias; 4) to be less confronting for the patient. The questionnaire is built on dimensions, whereas psychiatric diagnoses are built on categories. We will model the transition from one to the other. This approach will allow us to verify the hypotheses of diagnostic categories construction in psychopathology, integrated in the RDoC approach; and later on to standardize the psychometric measures used in cognitive-behavioral therapy treatments. 200 adults will undergo a standard clinical interview (SCID-5, First et al., 2017), and the psychological screening self-report questionnaire (D-Psy) and additional questionnaires measuring social desirability dissociation, phobia and autism.

Conditions

Psychopathology

Outcome Measures

Primary Outcomes (1)

• Prediction of SCID-5

  Predict the majority of SCID-5 pathologies (validity test) with a success rate significantly higher than chance.

  1 year

Secondary Outcomes (4)

• Dimensional structure of psychopathologies

  2 years

• Desirability bias

  18 monthes

• Ease-of-use

  18 monthes

• Non-confrontational questionnaire

  18 monthes

Study Arms (1)

Normal subjects with suspicion of psychopathological disorder

Adults over 18 years old who are fluent in French (oral and written). Participant with neurological or organic mental disorder (not induced by substances) including dementia, organic amnesic syndrome, delirium, other mental, personality or behavioural disorders due to brain damage, dysfunction or to physical disease.

Diagnostic Test: Psychopathology screening tests

Interventions

Psychopathology screening tests DIAGNOSTIC_TEST

The assessment phase includes the SCID-5 (First et al., 2017), the D-PSY questionnaire and standardized questionnaires. The D-PSY questionnaire and the SCID-5 (First et al., 2017) will be counterbalanced in terms of the order of administration, with half of the participants taking the SCID-5 (First et al., 2017) first and then the D-PSY questionnaire and the others standardized; the other half will take the D-PSY first and then the SCID-5 (First et al., 2017) and the other questionnaires. The other standardised questionnaires will be randomised for order of administration. These standardised questionnaires measure social desirability (Balanced Inventory of Desirable Responding, BIDR, Paulhus, 1985, 1991; in French: Cournoyer \& Sabourin, 1991), dissociation (DIS-Q, Vanderlinden et al., 1993), phobia (the Fear Questionnaire, F.Q., Marks \& Mathews, 1979; in French Cottraux et al., 1987) and autism (AQ, Baron-Cohen et al., 2001; in French, translation by Braun \& Kempenaers, 2007).

Normal subjects with suspicion of psychopathological disorder

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Normal adults with a suspicion of psychopathology

You may qualify if:

• Adults over 18 years old and less than 65 years old who are fluent in French (oral and written), with suspicions of psychopathology.
• Protected adults and pregnant women cannot participate.

You may not qualify if:

• Participant with neurological or organic mental disorder (not induced by substances) including dementia, organic amnesic syndrome, delirium;
• other mental, personality or behavioural disorders due to brain damage, dysfunction or to physical disease.

Sponsors & Collaborators

• Institut pour la Pratique et l'Innovation en PSYchologie appliquée (Institut Pi-Psy): lead
• BPIfrance: collaborator

Study Sites (1)

Centre Pi-Psy de Draveil

Draveil, Essonne, 91210, France

RECRUITING

Study Officials

• Aurore Vialatte, PhD

  Institut pour la Pratique et l'Innovation en PSYchologie appliquée (Institut Pi-Psy)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

François Vialatte, PhD

CONTACT

+33 (0)1 69 44 96 60; contact@pi-psy.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 29, 2022
• First Posted: January 9, 2023
• Study Start: October 11, 2022
• Primary Completion: March 31, 2023
• Study Completion: March 31, 2023
• Last Updated: January 9, 2023

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)