Anatomical Resection in Colorectal Liver Metastases Patients

NCT05673564 | Completed

• 1 other identifier: ARCRLM
• Study Type: observational
• Target: 729
• Locations: 0 countries
• Sites: N/A

Brief Summary

The type of liver resection (anatomical resection, AR or nonanatomical resection, NAR) for colorectal liver metastases (CRLM) is subject to debate. The debate may persist because some certain prognostic factors, associated with aggressive biological behavior of tumor, have been overlooked. The aim of our study was to investigate the characteristics of patients who would benefit more from anatomical resection for colorectal liver metastases.

Conditions

The Characteristics of CRLM Patients Who Would Benefit More From Anatomical Resection

Outcome Measures

Primary Outcomes (1)

• RFS

  Relapse-free survival since patients undergoing hepatic resection

  2012.6.1-2022.6.1

Secondary Outcomes (1)

• OS

  2012.6.1-2022.6.1

Study Arms (2)

anatomical resection group

Anatomical resection was defined as resection of 1 or more complete hepatic segments in our study, including bisegmentectomy, right hemihepatectomy, left hemihepatectomy, extended right hemihepatectomy, extended left hemihepatectomy, single segmentectomy, caudate lobectomy, or a combination of these.

Procedure: Anatomical Resection

nonanatomical resection group

Nonanatomical resection known as wedge resection, was defined as resection of the tumor with a margin of normal parenchyma without regard to hepatic anatomy.

Interventions

Anatomical Resection PROCEDURE

Based upon the segmental anatomy of the liver according to Couinaud system, AR was defined as resection of 1 or more complete hepatic segments in our study, including bisegmentectomy, right hemihepatectomy, left hemihepatectomy, extended right hemihepatectomy, extended left hemihepatectomy, single segmentectomy, caudate lobectomy, or a combination of these. NAR, known as wedge resection, was defined as resection of the tumor with a margin of normal parenchyma without regard to hepatic anatomy.

anatomical resection group

Eligibility Criteria

• Age: 18 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study was a retrospective cohort study based on our prospectively collected colorectal cancer database. All adult patients who underwent curative-intent liver resection for CRLM between June 2012 and May 2019 at Zhongshan Hospital in Shanghai and had available data on KRAS/NRAS/BRAF status, were eligible for inclusion.

You may qualify if:

• (1)Age 18-79 years;(2) Histologically proven colorectal adenocarcinoma;

You may not qualify if:

• (1) the histologic type of tumor was not called adenocarcinoma; (2) peritoneal metastasis; (3) number of liver metastasis \>3; (4) simultaneous anatomical and nonanatomical resections; (5) R2 resection; (6) history of previous hepatectomy; (7) incomplete data. The rest of patients were divided into 2 groups: patients undergoing an AR, and patients undergoing a NAR.

Sponsors & Collaborators

• Fudan University: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Colorectal Surgery

Study Record Dates

• First Submitted: January 4, 2023
• First Posted: January 6, 2023
• Study Start: June 1, 2012
• Primary Completion: May 1, 2019
• Study Completion: May 1, 2019
• Last Updated: January 6, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share