Intraoperative Conversion During Video-assisted Thoracoscopy Resection for Lung Cancer Does Not Alter Survival

NCT04663191 | Completed

• 1 other identifier: T38
• Study Type: observational
• Target: 843
• Locations: 1 country
• Sites: 1

Brief Summary

Anatomical resection with systematic lymph-node dissection is currently the standard of care for the treatment of early stage non-small cell lung cancer. The use of minimally invasive approaches has increased greatly over the last two decades \[either video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracoscopic surgery (RATS)\], as they provide the patient with better outcomes than open thoracotomy. Minimally invasive VATS lobectomy for a standard case is generally a straightforward procedure for a well-trained surgical team, although concomitant preoperative pathologies or intraoperative findings/adverse events may result in technical difficulties, leading to intraoperative conversion, commonly by thoracotomy. The investigators aimed to assess long-term outcomes in a consecutive cohort of patients treated by anatomical pulmonary resection either using VATS, VATS requiring intraoperative conversion to thoracotomy, or upfront open thoracotomy for lung-cancer surgery.

Conditions

Video-assisted Thoracoscopic Surgery; Lung Cancer; Lobectomy; Survival; Surgery

Keywords

video-assisted thoracoscopic surgery; lung-cancer surgery; intraoperative conversion to open surgery; lobectomy; survival

Outcome Measures

Primary Outcomes (1)

• Overall survival during the follow-up period after surgery

  from day of surgery up to 7 years

Study Arms (3)

Full VATS

Procedure: anatomical resection

VATS with conversion

Procedure: anatomical resection

Thoracotomy upfront

Procedure: anatomical resection

Interventions

anatomical resection PROCEDURE

Anatomical resection with systematic lymph-node dissection

Full VATS; Thoracotomy upfront; VATS with conversion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients treated by anatomical lobar pulmonary resection (lobectomy, bilobectomy) or anatomical sublobar pulmonary resection (segmentectomy) for non-small cell lung cancer (NSCLC), either by VATS (eventually with intraoperative conversion) or upfront thoracotomy.

You may qualify if:

• All consecutive patients treated by anatomical lobar pulmonary resection (lobectomy, bilobectomy) or anatomical sublobar pulmonary resection (segmentectomy) for non-small cell lung cancer (NSCLC), either by VATS (eventually with intraoperative conversion) or upfront thoracotomy.

You may not qualify if:

• patients with non-anatomical pulmonary resection (wedge resection)
• patients with a histology other than NSCLC (benign or metastatic from another primitive cancer), stage IV NSCLC disease,
• patients with multiple primary NSCLC (synchronous or metachronous)
• patients with incomplete resection (R+)
• patient for whom a VATS approach was never considered

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens

Amiens, 80480, France

Location

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2020
• First Posted: December 10, 2020
• Study Start: January 2, 2020
• Primary Completion: December 2, 2020
• Study Completion: December 3, 2020
• Last Updated: December 16, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)