Early Versus Late Use of Hi-VNI in Covid-19

NCT05663138 | Completed

• 1 other identifier: Hi-VNI in covid 19 patients
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluate early administration of high-velocity nasal insufflation in COVID-19 patients presented with acute respiratory failure after failure of conventional low flow nasal cannula bypassing the escalating step of Non re-breathing mask where early use of High velocity nasal insufflations achieved better improvement of respiratory distress, lower oxygen requirements and shorter ICU stay.

Conditions

COVID-19

Keywords

Hi-VNI; Covid-19

Outcome Measures

Primary Outcomes (1)

• Improved oxygenation

  Patients with early use of Hi-VNI had better improvement of oxygenation than those with late use of Hi-VNI

  through the study completion, average 6 months

Study Arms (2)

Early Hi-VNI

Group 1 of early shift to Hi-VNI after nasal cannula

Late Hi-VNI

Group 2 of late use of Hi-VNI after NRM

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed as COVID-19 presented with respiratory failure and admitted to intensive care of COVID-19 zone, chest Department, Assiut University hospital, Patients who failed on either low flow nasal cannula or non-rebreathing mask were shifted to Hi-VNI device using a Precision flow vapotherm (vapotherm, Inc, 100 Domain device Exeter, NH 03833, T: 603-658-0011, USA). Patients were classified into 2 groups: Early and late Hi-VNI groups according to whether the shift to Hi-VNI occurred after low flow nasal cannula or non-rebreathing mask respectively.

You may qualify if:

• severe COVID Patients with hypoxemic respiratory failure. 2- Patients with no comorbidities

You may not qualify if:

• Non severe COVID Patients
• Patients with comorbidities (e.g chronic chest dis, DM, renal failure and hepatic failure
• Patients indicated for mechanical ventilation
• Patients with marked hypercapnia in need for non-invasive ventilation

Sponsors & Collaborators

• Assiut University: lead
• Aswan University: collaborator

Study Sites (1)

Assiut University

Asyut, 71111, Egypt

Location

Related Publications (2)

• Granton D, Chaudhuri D, Wang D, Einav S, Helviz Y, Mauri T, Mancebo J, Frat JP, Jog S, Hernandez G, Maggiore SM, Hodgson CL, Jaber S, Brochard L, Trivedi V, Ricard JD, Goligher EC, Burns KEA, Rochwerg B. High-Flow Nasal Cannula Compared With Conventional Oxygen Therapy or Noninvasive Ventilation Immediately Postextubation: A Systematic Review and Meta-Analysis. Crit Care Med. 2020 Nov;48(11):e1129-e1136. doi: 10.1097/CCM.0000000000004576.

  PMID: 32947472 BACKGROUND

• Hernandez G, Vaquero C, Colinas L, Cuena R, Gonzalez P, Canabal A, Sanchez S, Rodriguez ML, Villasclaras A, Fernandez R. Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in High-Risk Patients: A Randomized Clinical Trial. JAMA. 2016 Oct 18;316(15):1565-1574. doi: 10.1001/jama.2016.14194.

  PMID: 27706464 BACKGROUND

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Lamees M Bakkar, Fellow

  Fellow of Chest diseases Assiut University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: clinical professor

Study Record Dates

• First Submitted: December 20, 2022
• First Posted: December 23, 2022
• Study Start: October 1, 2021
• Primary Completion: February 28, 2022
• Study Completion: March 15, 2022
• Last Updated: December 23, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)