Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage

NCT05658445 | Completed

• 1 other identifier: As
• Study Type: observational
• Target: 86
• Locations: 1 country
• Sites: 1

Brief Summary

The definition of recurrent spontaneous abortion (RSA) has changed over the years, and most societies now advocate defining RSA as two or three consecutive or discontinuous miscarriages with the same sexual partner before 24 weeks gestation In recent years, the incidence of this disease has been on the rise, occurring in about 1%- 5% of pregnancy in women at childbearing age, and the success rate of second pregnancy in RSA females has been significantly reduced The etiology of RSA is extremely complex, including anatomical factors, genetic factors, endocrine factors, infectious and immune factors, and pre-thrombosis etiology. However, the cause of the disease is unclear in half of patients and known as unexplained recurrent spontaneous abortion (URSA)

Conditions

Abortion, Habitual

Keywords

RSA

Outcome Measures

Primary Outcomes (1)

• Define a novel hypothesis that may explain the aetiology of URSA

  within 3 years

Study Arms (2)

cases

Female with recurrent unexplained abortion

Other: evacuation

control

female with normal labour

Other: evacuation

Interventions

evacuation OTHER

after complete evacuation of uterus follow abortion

cases; control

Eligibility Criteria

• Age: 20 Years - 30 Years
• Gender Eligibility Details: only females with URSA
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Female without cancer or chronic illness that exposed to 2 or 3 consecutive or discontinues abortion

You may qualify if:

• Female with unexplained two or three consecutive or discontinuous miscarriages with the same sexual partner

You may not qualify if:

• Female with one miscarriage
• Female with explained causes of miscarriage
• Female with cancer
• Female with chronic illness.
• Pregnant women above 30

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Medical Bochemistry Department

Asyut, Assuit, Egypt

Location

Biospecimen

Retention: SAMPLES WITH DNA

placental samples (4×6 cm) will be collected from women with miscarriage. Placental tissue from healthy controls (females with normal or caesarean labour)will also be collected. Tissue samples will be removed from the central region of the placenta and processed within 30 min. All samples will be repeatedly rinsed with cold phosphate buffered saline (PBS), and maintained at -80 °C until genetic study of miR-410-5p expression, Integrin alpha-6gene expression and Baculoviral IAP Repeat Containing 7(BIRC7) expression by qRTPCR.

MeSH Terms

Conditions

Abortion, Habitual

Interventions

Emergency Shelter

Condition Hierarchy (Ancestors)

Abortion, Spontaneous; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Disasters; Environment; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: faculty of medicine Assuit university

Study Record Dates

• First Submitted: December 12, 2022
• First Posted: December 20, 2022
• Study Start: January 1, 2023
• Primary Completion: April 1, 2025
• Study Completion: June 1, 2025
• Last Updated: December 31, 2025

Record last verified: 2023-12

Locations

EG (1)