Quinolone Resistance Profiles and Mechanisms of Staphylococcus Aureus and Escherichia Coli From Humans, Chicken and Catfish Farms in Indonesia

NCT05652556 | Unknown

• 1 other identifier: QUINDO
• Study Type: observational
• Target: 480
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to reveal quinolone resistance profiles and mechanisms in S. aureus and E. coli in the human, animal and aquaculture sector in Blitar, Indonesia. The main questions it aims to answer are:

• Obtain the quinolone resistance profiles and mechanisms of S. aureus and E. coli in human health, animal health and aquaculture health sector in Blitar, Indonesia.
• Obtain the association of AMR and AMU data within and between the human health, animal health and aquaculture health sector in Blitar, for quinolones.

Conditions

Drug Resistance, Microbial

Keywords

Escherichia coli; Staphylococcus aureus; Fluoroquinolones

Outcome Measures

Primary Outcomes (1)

• Quinolone resistance profiles and mechanisms of S. aureus and E. coli in human health, animal health and aquaculture health sector in Blitar

  As determined by Vitek, microdilution, and whole genome sequencing.

  2023

Secondary Outcomes (1)

• Association of AMR and AMU data within and between the human health, animal health and aquaculture health sector in Blitar, for quinolones

  2023

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Farmers of included farms and non-farmers. Non-farmers will be approached via public health center (puskesmas).

You may qualify if:

• Informed consent

You may not qualify if:

• none

Sponsors & Collaborators

• Erasmus Medical Center: lead
• Dr. Soetomo General Hospital: collaborator
• Balai Besar Laboratorium Kesehatan (BBLK) Surabaya: collaborator
• National Institute of Health Research and Development, Ministry of Health Republic of Indonesia: collaborator
• Directorate of Veterinary Public Health, Ministry of Agriculture, Indonesia: collaborator
• Directorate of Animal Health, Ministry of Agriculture, Indonesia: collaborator
• Ministry of Marine and Fisheries, Indonesia: collaborator
• Utrecht University: collaborator
• Radboud University Medical Center: collaborator
• National Institute for Public Health and the Environment (RIVM): collaborator

Biospecimen

Retention: SAMPLES WITHOUT DNA

Culture of nasal and rectal swabs.

MeSH Terms

Conditions

Escherichia coli Infections; Staphylococcal Infections

Condition Hierarchy (Ancestors)

Enterobacteriaceae Infections; Gram-Negative Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Gram-Positive Bacterial Infections

Study Officials

• Juliëtte A. Severin, MD PhD

  Erasmus Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Juliëtte A. Severin, MD PhD

CONTACT

+31107033510; j.severin@erasmusmc.nl

Tri Pudy Asmarawati, MD

CONTACT

+62315018436; tpasmarawati@fk.unair.ac.id

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor, Medical coordinator Unit infection prevention

Study Record Dates

• First Submitted: December 7, 2022
• First Posted: December 15, 2022
• Study Start: December 9, 2022
• Primary Completion: January 1, 2023
• Study Completion: March 31, 2023
• Last Updated: December 15, 2022

Record last verified: 2022-12