Longitudinal FolloW-up of Antimicrobial Resistance From Perinatal Acquisition (LWAPA): A SHARE Study ASSESSING AND PREVENTING Antimicrobial Resistance in the Perinatal Period

NCT06617260 | Active Not Recruiting

• 2 other identifiers: 855283Antimicrobial resistance(AMR),
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

In 2022, in collaboration between the Botswana Ministry of Health (MOH), the U.S. Centers for Disease Control \& Prevention, and the Botswana-UPenn Partnership (BUP), a program was launched called, "Surveillance of Healthcare-associated infections \& Antimicrobial Resistance", or "SHARE". The aims of SHARE are to 1) enhance laboratory capacity to detect emerging AMR patterns; 2) strengthen hospital epidemiology programs, leveraging data to prevent, detect, and contain emerging AMR threats; 3) deploy study teams to answer critical public health surveillance questions, and 4) to build a national network of hospital infection prevention and control (IPC) resources to prevent, detect, and contain emerging infectious disease threats.

Conditions

Drug Resistance, Microbial

Keywords

Antimicrobial

Outcome Measures

Primary Outcomes (1)

• Longitudinal FolloW-up of Antimicrobial Resistance from Perinatal Acquisition

  Ultimately, the goal of the LWAPA study is to better understand perinatal transmission of AMR in order to inform prevention measures

  12 months

Study Arms (1)

Neonates and mothers

Pre-partum mothers will be eligible for recruitment if they have been admitted to the pre-partum ward (2F) at PMH. This includes mothers with: * Pre-term labor (24-36 weeks gestation) * Pre-eclampsia * Post-dates (\>41 weeks gestation) The rationale for recruiting these mothers is that there is a high probability of having a baby who will ultimately be admitted to the NNU

Eligibility Criteria

• Age: 36 Weeks+
• Gender Eligibility Details: Pre partum mothers
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pre-partum mothers will be eligible for recruitment if they have been admitted to the pre-partum ward (2F) at PMH. This includes mothers with: * Pre-term labor (24-36 weeks gestation) * Pre-eclampsia * Post-dates (\>41 weeks gestation) The rationale for recruiting these mothers is that there is a high probability of having a baby who will ultimately be admitted to the NNU

You may qualify if:

• Pre-partum mothers will be eligible for recruitment if they have been admitted to the pre-partum ward (2F) at PMH. This includes mothers with:
• Pre-term labor (24-36 weeks gestation)
• Pre-eclampsia
• Post-dates (\>41 weeks gestation)-

You may not qualify if:

• Mothers/babies who have been admitted for more than 96 hours will be excluded

Sponsors & Collaborators

• University of Pennsylvania: lead

Study Sites (1)

Princess Marina Hospital

Gaborone, 267, Botswana

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Rectovaginal swabs

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: September 25, 2024
• First Posted: September 27, 2024
• Study Start: February 15, 2024
• Primary Completion (Estimated): February 28, 2027
• Study Completion (Estimated): February 28, 2027
• Last Updated: November 19, 2025

Record last verified: 2025-11

Locations

BO (1)