Differences in Length of Telomere in Food Addicted vs Non Food Addicted Persons

NCT05649189 | Completed

• 1 other identifier: 0122-21-EP
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this descriptive study is to examine telomere length between two groups of people, those with and those without food addiction and identify possible relationships that may play a role in food addiction, it's behaviors and consequences. Research subjects would be adults age 19-70. They would be recruited from the Rural Nebraska Panhandle population. All COVID precautions will be enforced. Human subjects safety plans will be in place for this study.Eligibility: YaleFAS-2 Food Addiction Scale will be used to screen for presence or absence of food addiction. AT a later time, Eligible persons will be given the research consent form to read through and determine if they want to become a participant. If so, they will be consented. The participants will then be assigned an identification number to maintain confidentiality. Intervention: Participants will be given a Oragene saliva DNA collection kit to use and return to investigators. Evaluation:The Oragene saliva DNA collection kit will then be sent in for telomere length testing. Telomere Results will be correlated with food addiction diagnoses and behaviors to identify potential relationships. Follow up: Publication of results

Conditions

Food Addiction

Outcome Measures

Primary Outcomes (1)

• telomere length

  cross sectional saliva sample from which telomere length is measured

  at baseline only

Study Arms (2)

Participants testing positive for Food Addiction (FA)

these participants have tested positive for Food Addiction (FA) at a severe level using the YaleFAS-2 Food Addiction Scale.

Diagnostic Test: telomere length measure

Participants testing negative for Food Addiction (FA)

these participants have tested negative for Addiction (FA) using the YaleFAS-2 Food Addiction Scale.

Diagnostic Test: telomere length measure

Interventions

telomere length measure DIAGNOSTIC_TEST

length of telomere between two groups

Participants testing negative for Food Addiction (FA); Participants testing positive for Food Addiction (FA)

Eligibility Criteria

• Age: 19 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All those enrolled (n = 120) were adults (age 19-70) with overweight/obesity (BMI ≥ 25). Half were positive for severe FA (≥ 6 symptoms plus clinical significance) and half were negative for FA (≤ 1 symptom and no clinical significance). These criteria were selected to best define the FA+ and FA- subtypes (Aguirre et al., 2022). Most participants were female (87.5%) and Caucasian (65%). The remainder were Latino (24%), African American (7%), Asian (4%), or Native American (2%). Reported health conditions include diabetes (n = 5), hypertension (n = 20), smoking (n = 4).

You may qualify if:

• Obese Food addicted persons between ages 19 and 70
• Obese Non Food addicted persons between ages 19 and 70

You may not qualify if:

• persons with active liver disease
• persons with active cancer

Sponsors & Collaborators

• University of Nebraska: lead
• University of Washington: collaborator
• University of California, San Francisco: collaborator

Study Sites (1)

University of Nebraska Medical Center, College of Nursing

Scottsbluff, Nebraska, 69361, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

saliva

MeSH Terms

Conditions

Food Addiction

Condition Hierarchy (Ancestors)

Behavior, Addictive; Compulsive Behavior; Impulsive Behavior; Behavior; Feeding and Eating Disorders; Mental Disorders

Study Officials

• Trina M Aguirre, PhD

  University of Nebraska

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 3, 2022
• First Posted: December 13, 2022
• Study Start: October 17, 2021
• Primary Completion: March 15, 2022
• Study Completion: March 15, 2022
• Last Updated: January 9, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)