Hydroxychloroquine Combined With Gemcitabine in the Treatment of Advanced Non-small Cell Lung Cancer

NCT05647330 | Unknown Phase 2

• 1 other identifier: 2022213
• Study Type: interventional
• Target: 55
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the efficacy and safety of hydroxychloroquine (600mgBID) combined with gemcitabine (1000mg/m2,d1,8) in the third-line and above treatment of advanced NSCLC.

Conditions

Hydroxychloroquine; Gemcitabine; Lung Neoplasms

Outcome Measures

Primary Outcomes (1)

• Objective response rate(ORR)

  The proportion of patients whose tumor volume reduction reaches the predetermined value and can maintain the minimum time limit is the sum of the proportion of complete and partial remission.

  1years

Secondary Outcomes (3)

• Disease control rate(DCR)

  2 years

• Progression-free survival(PFS)

  2 years

• Overall survival(OS)

  2 years

Study Arms (1)

Hydroxychloroquine combined with gemcitabine

EXPERIMENTAL

1. Hydroxychloroquine sulfate tablets: twice a day, each time (600mg). Continuous oral administration. Until the disease progresses or becomes intolerable. 2. gemcitabine was administered intravenously at a dose of 1000mg/m2 for 30min,d1, 8, and every 3 weeks (21 days) until disease progression or intolerable toxicity, with a maximum duration of 2 years.

Drug: Hydroxychloroquine Combined With Gemcitabine

Interventions

Hydroxychloroquine Combined With Gemcitabine DRUG

Hydroxychloroquine combined with chemotherapy

Also known as: chloroquine

Hydroxychloroquine combined with gemcitabine

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients must have histologically or cytologically proven advanced lung squamous cell carcinoma or lung adenocarcinoma with negative EGFR and ALK gene mutations.
• Patients must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) criteria, meaning that at least one lesion can be accurately measured by conventional techniques of CT or MRI.
• It is acceptable for patients who have received radiotherapy. It must be at least 4 months after radiotherapy, and all signs of toxicity must abate.
• The patient must be 18 years of age or above.
• The ECOG performance status of patients must be 0-1.
• Patients should not become pregnant or breastfeed because chemotherapy is considered to pose significant risks to the fetus/baby.
• The patient must have a life expectancy of more than three months.
• Patients must be able to understand and willing to sign written informed consent.
• Previously received systematic treatment with 2 regimens;
• Treatment with hydroxychloroquine sulfate tablets plus gemcitabine is required to be initiated within 28 days after informed consent;
• The function of vital organs should meet the following requirements as far as possible (if laboratory test values do not meet the following criteria, they can also be included in the registration after comprehensive evaluation by researchers) :
• Absolute neutrophil count ≥1.5×109/L;
• Platelets ≥80×109/L;
• Hemoglobin ≥9g/dL;
• Serum albumin ≥ 3G /dL;

You may not qualify if:

• Patients with rapid progression after 1 or 2 cycles in first-line and second-line regimens.
• Persons with known allergies or metabolic disorders to any drug in the treatment regimen.
• Patients who had previously received hydroxychloroquine.
• Patients with known G6PD deficiency, severe psoriasis, porphyria, macular degeneration, or severe diabetic retinopathy were ineligible because of the potential for greater hydroxychloroquine toxicity.
• Symptomatic central nervous metastasis. Patients with asymptomatic brain metastases or stable brain metastases after treatment were eligible to participate in the study if they met all the following criteria: measurable lesions outside the central nervous system; No mesencephalon, pons, cerebellum, meninges, medulla oblongata or spinal cord metastases; Maintain clinical stability for at least 2 weeks.
• A history of psychotropic drug abuse, alcoholism or drug abuse;
• In the 6 months prior to study entry, the following conditions occurred: myocardial infarction, severe/unstable angina pectoris, New York Heart Association (NYHA) grade 2 or higher cardiac dysfunction, and poorly controlled arrhythmias (including QT c F interval men \& GT; 450 m s, female \& GT; 470 ms, QT cF interval calculated by Fridericia formula), symptomatic congestive heart failure, cerebrovascular accident (including transient ischemic attack or symptomatic pulmonary embolism);
• Human immunodeficiency virus (HIV, HIV 1/2 antibody) positive; Acute or chronic active hepatitis B (HBsAg positive and HBV DNA \& g t; 1\*103/ml) or acute or chronic active hepatitis C (HCV antibody positive and HCV RNA \& g t; 15 iu/ml); Active pulmonary tuberculosis;
• Other factors that may affect patient safety or compliance as determined by the investigator. If there is a serious illness (including mental illness) that requires concomitant treatment, serious laboratory abnormalities, or other family or social factors.
• Patients deemed inappropriate for enrollment by the investigator.

Sponsors & Collaborators

• Henan Cancer Hospital: lead

MeSH Terms

Conditions

Lung Neoplasms

Interventions

Gemcitabine; Chloroquine

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Heterocyclic Compounds; Deoxycytidine; Cytidine; Pyrimidine Nucleosides; Pyrimidines; Heterocyclic Compounds, 1-Ring; Aminoquinolines; Quinolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 15, 2022
• First Posted: December 12, 2022
• Study Start: December 15, 2022
• Primary Completion: October 1, 2024
• Study Completion: October 1, 2025
• Last Updated: December 12, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share