NCT05646355

Brief Summary

The proposed study is a randomized controlled pilot trial designed to assess the effectiveness and acceptability of a proactive screening outreach program on colorectal cancer screening rates on eligible patients in the Flatbush Family Health Center medical practice.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
109

participants targeted

Target at P25-P50 for not_applicable colorectal-cancer

Timeline
Completed

Started Mar 2023

Shorter than P25 for not_applicable colorectal-cancer

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 2, 2022

Completed
10 days until next milestone

First Posted

Study publicly available on registry

December 12, 2022

Completed
3 months until next milestone

Study Start

First participant enrolled

March 15, 2023

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 11, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 11, 2023

Completed
1 year until next milestone

Results Posted

Study results publicly available

December 27, 2024

Completed
Last Updated

December 27, 2024

Status Verified

December 1, 2024

Enrollment Period

9 months

First QC Date

December 2, 2022

Results QC Date

November 25, 2024

Last Update Submit

December 19, 2024

Conditions

Outcome Measures

Primary Outcomes (2)

  • Number of Participants Who Complete Initial Fecal Immunochemical Test (FIT) at 6 Months

    Number of Participants who completed CRC screening via FIT by 6 months past the start of intervention

    Up to Month 6

  • Number of Participants Who Completed Colonoscopy at 6 Months

    Number of Participants who underwent colonoscopy by 6 months past the start of intervention

    Up to Month 6

Secondary Outcomes (1)

  • Number of Participants With Positive FIT Test Who Complete Colonoscopy at 6 Months

    Up to Month 6

Study Arms (2)

Proactive Screening Outreach

EXPERIMENTAL

Participants will receive a letter from their clinic explaining CRC screening options (fecal immunochemical test (FIT) vs colonoscopy) including a FIT kit with completion and return instructions. The letter will also include information for navigation to a screening colonoscopy instead of FIT testing, if deemed to be the participant's preference. Approximately 10-14 days after mailing the FIT kit, participants who have not completed screening will receive a telephone call (with voice message left) and text message, querying whether the FIT kit was received and reminding the participant to complete the test or request a new kit, if needed. If the FIT kit has not been submitted after about two weeks from the reminder call/text message, the study team will mail a final letter to the participant on behalf of the clinic, reminding them to complete and return the FIT kit.

Behavioral: Proactive CRC Screening Outreach

Usual Care

ACTIVE COMPARATOR

Individuals in the usual care group will not be approached or notified of their enrollment in the study.

Behavioral: Usual Care

Interventions

Proactive approach that incorporates a mailed outreach invitation to screen with fecal immunochemical testing (FIT), followed by active assistance to colonoscopy completion if preferred or indicated by FIT test result.

Proactive Screening Outreach
Usual CareBEHAVIORAL

Participants will not receive additional outreach from the study team regarding CRC screening.

Usual Care

Eligibility Criteria

Age45 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Receiving medical care at Flatbush FHC
  • Due or overdue for CRC screening

You may not qualify if:

  • Age younger than 45 years old or greater than 75 years old
  • Up-to-date with colorectal cancer screening (FIT within 1 year or colonoscopy within 10 years)
  • History of colorectal cancer, inflammatory bowel disease or colorectal polyps
  • No address or phone number on file
  • FIT test ordered within 6 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

NYU Brooklyn Family Health Centers

Brooklyn, New York, 11220, United States

Location

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal Diseases

Results Point of Contact

Title
Aasma Shaukat
Organization
NYU Langone Health

Study Officials

  • Aasma Shaukat

    NYU Langone Health

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 2, 2022

First Posted

December 12, 2022

Study Start

March 15, 2023

Primary Completion

December 11, 2023

Study Completion

December 11, 2023

Last Updated

December 27, 2024

Results First Posted

December 27, 2024

Record last verified: 2024-12

Data Sharing

IPD Sharing
Will share

The de-identified participant data from the final research dataset will be shared upon reasonable request beginning 9 to 36 months after publication or as required by a condition of awards or supporting agreements, provided the requesting investigator executes a data use agreement with NYU Langone Health. This instance of data sharing will also require separate IRB review as well as review from NYU Langone's Data Sharing Strategy Board (DSSB). Requests should be directed to: Aasma.Shaukat@nyulangone.org. The protocol and statistical analysis plan will be posted on Clinicaltrials.gov only as required by federal regulation or supporting awards and agreements.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Beginning 9 months and ending 36 months following article publication or as required by a condition of awards and agreements supporting the research.
Access Criteria
The investigator who proposed to use the data will be provided access upon reasonable request. Requests should be directed to Aasma.Shaukat@nyulangone.org. To gain access, data requestors will need to sign a data access agreement.

Locations