Is Monocyte/HDL Ratio a Predictor of Mortality in Aortic Valve Surgery

NCT05641584 | Completed

• 1 other identifier: 2022/155
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, the investigators aimed to determine whether the preoperative Monocyte/HDL ratio would be a predictor of postoperative mortality and morbidity in patients who underwent aortic valve replacement due to aortic stenosis.

Conditions

Inflammation; Aortic Valve Stenosis; HDL

Outcome Measures

Primary Outcomes (2)

• mortality

  The investigators aimed to determine whether the preoperative Monocyte/HDL ratio would be a predictor of postoperative mortality in patients who underwent aortic valve replacement due to aortic stenosis.

  6 month

• morbidity

  The investigators aimed to determine whether the preoperative Monocyte/HDL ratio would be a predictor of postoperative mortality and The investigators aimed to determine whether the preoperative Monocyte/HDL ratio would be a predictor of postoperative mortality and morbidity in patients who underwent aortic valve replacement due to aortic stenosis. in patients who underwent aortic valve replacement due to aortic stenosis.

  6 month

Secondary Outcomes (1)

• Inflammation

  6 month

Interventions

retrospective data review study OTHER

Patient information will be scanned retrospectively from the computer environment and patient cards. No intervention will be made to the patients.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients included in the study Adult patients (aged ≥18 years) with ASA II-IV who underwent elective aortic valve replacement under Cardiopulmonary bypass (CPB) for aortic stenosis in our clinic between January 1, 2010 and March 31, 2022, were retrospectively scanned from the computer system and patient cards, and included in the study.

You may qualify if:

• be over the age of 18, ASA II-IV Patients scheduled for cardiac surgery due to on-pomp aortic valve replacement

You may not qualify if:

• emergency operations, off pump)pumpless surgery, revision (repetitive) operations, those with signs of acute infection, those with autoimmune disease, those with severe renal (serum creatinine \>2.0 mg/dl) disease, those with severe hepatic disease, those with suspected malignancy, patients where data variables cannot be saved due to technical problems.

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead

Study Sites (1)

ISTANBUL Bakırkoy Dr. Sadi Konuk Training and Research Hospital,

Istanbul, Bakırköy, 34147, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Inflammation; Aortic Valve Stenosis

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Aortic Valve Disease; Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases; Ventricular Outflow Obstruction

Study Officials

• tuğba yücel, md

  Bakirkoy Dr Sadi Konuk Traning Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 29, 2022
• First Posted: December 7, 2022
• Study Start: May 10, 2022
• Primary Completion: July 10, 2022
• Study Completion: July 10, 2022
• Last Updated: December 14, 2022

Record last verified: 2022-12

Locations

TU (1)