The Prevalence of Malnutrition and Sarcopenia in Swiss Rehabilitation Settings

NCT05639985 | Completed DMC

• 1 other identifier: 2022-01098
• Study Type: observational
• Target: 550
• Locations: 1 country
• Sites: 5

Brief Summary

The aim of the study is to identify the prevalence of malnutrition and sarcopenia in patients admitted in Swiss rehabilitation centers. Furthermore, the aim is to investigate the changes of selected malnutrition and sarcopenia parameters over the length of the rehabilitation stay.

Conditions

Malnutrition; Sarcopenia

Keywords

malnutrition; sarcopenia; rehabilitation; prevalence; Nutritional Risk Screening; handgrip strength

Outcome Measures

Primary Outcomes (10)

• Prevalence of malnutrition - Risk for malnutrition

  The risk for malnutrition will be screened by the Nutritional Risk Screening (NRS-2002, in points). NRS has a scale from 0 to 7 points; higher points indicate a higher risk for malnutrition.

  Within 7 days after admission

• Body weight

  (in kg)

  Within 7 days after admission

• Height

  (in cm)

  Within 7 days after admission

• Body Mass Index

  (calculated by weight and height in kg/m2)

  Within 7 days after admission

• Weight loss

  Weight loss (in percent in six categories - \<5 percent within the last 6 months, 5-10 percent within the last 6 months, \>10 percent within the last 6 months; \<10 percent in more than 6 months, 10 -20 percent in more than 6 months, \>20 percent in more than 6 months)

  Within 7 days after admission

• Reduced energy intake

  Reduced energy intake (in percent of intake versus requirement in three categories: less than 50 percent of energy requirement covered for more than 1 week, any reduced energy intake versus requirement for \>2 weeks, no reduced energy intake)

  Within 7 days after admission

• Muscle mass by Bioelectrical Impedance Analysis (BIA) - Part 1

  Resistance (in Ohm) and Reactance (in Ohm)

  Within 7 days after admission

• Muscle mass by Bioelectrical Impedance Analysis (BIA) - Part 2

  Resistance (in Ohm) and Reactance (in Ohm) measured with BIA are combined with further information on weight, height, sex and age to calculate the appendicular skeletal muscle mass index (in kg/m2)

  Within 7 days after admission

• Prevalence of malnutrition - Confirmed diagnosis and severity of malnutrition

  In case of positive screening, diagnosis of malnutrition will be confirmed and severity assessed according to the Global Leadership Initiative on Malnutrition (GLIM) criteria using the following measures described above: weight (in kg); height (in cm); Body Mass Index (calculated by weight and height in kg/m2); weight loss (in percent in six categories - \<5 percent within the last 6 months, 5-10 percent within the last 6 months, \>10 percent within the last 6 months; \<10 percent in more than 6 months, 10 -20 percent in more than 6 months, \>20 percent in more than 6 months); reduced energy intake (in percent of intake versus requirement in three categories: less than 50 percent of energy requirement covered for more than 1 week, any reduced energy intake versus requirement for \>2 weeks, no reduced energy intake); Bioelectrical impedance analysis for muscle mass: resistance (in Ohm), reactance (in Ohm), Appendicular skeletal muscle mass index (in kg/m2)

  Within 7 days after admission

• Prevalence of malnutrition - overall

  Overall prevalence of malnutrition will be reported in percent

  Calculated through study completion after five months recruitment duration

Secondary Outcomes (10)

• Prevalence of sarcopenia - Risk for sarcopenia by SARC-F

  Within 7 days after admission

• Prevalence of sarcopenia - Risk for sarcopenia by handgrip strength

  Within 7 days after admission

• Prevalence of sarcopenia - Risk for sarcopenia

  Within 7 days after admission

• Prevalence of sarcopenia - Diagnosis of sarcopenia

  Within 7 days after admission

• Prevalence of sarcopenia - Severity of sarcopenia

  Within 7 days after admission

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Inpatients in rehabilitation clinic

You may qualify if:

• Patients treated in the following groups of rehabilitations will be included:
• Geriatric rehabilitation
• Pulmonal rehabilitation
• Cardiovascular rehabilitation
• Neurological rehabilitation
• Musculoskeletal rehabilitation
• Internistic rehabilitation and oncological rehabilitation

You may not qualify if:

• Inability to give informed consent
• Inability to follow study procedures (e.g., due to delirium or language barriers)
• Expected life expectancy \< 3 months and/or palliative care
• Isolation for example due to Covid-19 infection or tuberculosis
• Severe dehydration/ volume overload
• Medical conditions that prevent conducting a Bioelectrical Impedance Analysis (BIA) measurement (e.g. non-removable plasters or bandages at feet or hands) or defibrillator

Sponsors & Collaborators

• Undine Lehmann, Dr.: lead
• Berner Reha Zentrum AG: collaborator
• Klinik Barmelweid: collaborator
• University Department of Geriatric Medicine FELIX PLATTER: collaborator
• Zürcher RehaZentrum Wald: collaborator
• Rehab Basel: collaborator

Study Sites (5)

Klinik Barmelweid AG

Barmelweid, 5017, Switzerland

Location

REHAB Basel

Basel, 4055, Switzerland

Location

University Department of Geriatric Medicine FELIX PLATTER

Basel, 4055, Switzerland

Location

Berner Reha Zentrum AG

Heiligenschwendi, 3625, Switzerland

Location

Zürcher RehaZentren - Klinik Wald

Wald, 8636, Switzerland

Location

Related Publications (3)

• Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, Baptista G, Barazzoni R, Blaauw R, Coats A, Crivelli A, Evans DC, Gramlich L, Fuchs-Tarlovsky V, Keller H, Llido L, Malone A, Mogensen KM, Morley JE, Muscaritoli M, Nyulasi I, Pirlich M, Pisprasert V, de van der Schueren MAE, Siltharm S, Singer P, Tappenden K, Velasco N, Waitzberg D, Yamwong P, Yu J, Van Gossum A, Compher C; GLIM Core Leadership Committee; GLIM Working Group. GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community. Clin Nutr. 2019 Feb;38(1):1-9. doi: 10.1016/j.clnu.2018.08.002. Epub 2018 Sep 3.

  PMID: 30181091 BACKGROUND

• Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169.

  PMID: 30312372 BACKGROUND

• Kondrup J, Rasmussen HH, Hamberg O, Stanga Z; Ad Hoc ESPEN Working Group. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003 Jun;22(3):321-36. doi: 10.1016/s0261-5614(02)00214-5.

  PMID: 12765673 BACKGROUND

MeSH Terms

Conditions

Malnutrition; Sarcopenia

Condition Hierarchy (Ancestors)

Nutrition Disorders; Nutritional and Metabolic Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Thimo Marcin, Dr.

  Berner Reha Zentrum

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: October 28, 2022
• First Posted: December 7, 2022
• Study Start: November 1, 2022
• Primary Completion: March 31, 2023
• Study Completion: April 14, 2023
• Last Updated: April 25, 2023

Record last verified: 2023-04

Locations

CH (5)