Effects of Obesity on Rectus Femoris Muscle Thickness, Sarcopenia, Gait and Balance in Women

NCT05638035 | Unknown

• 1 other identifier: DSA2022
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

Research; It is a planned, non-invasive, controlled study in obese female volunteers and non-obese female volunteers. The population of the study consists of voluntarily non-obese women and obese women. Sarcopenia assets of individuals will be measured with the sarc-f questionnaire, and then muscle strength, muscle mass and physical performance tests will be measured. Then, rectus femoris muscle thickness will be measured with USG, and then walking and balance will be measured with ZEBRIS.

Conditions

Sarcopenic Obesity; Sarcopenia; Obesity

Outcome Measures

Primary Outcomes (1)

• Rectus femoris muscle thickness

  Measurement of muscle thickness with ultrasound

  baseline

Study Arms (2)

non-obese women

After obtaining demographic information for women with a BMI of 18-27.9 kg/m2 for at least 6 months, Body Mass Index (BMI) will be calculated and the relationship between rectus femoris muscle thickness, sarcopenia, gait and balance will be evaluated and will be compared with obese group.

Diagnostic Test: Ultrasonografi, Sarcopenia measurement, Zebris

obese women

After obtaining demographic information in women with a BMI of 30-39.9 kg/m2, Body Mass Index (BMI) will be calculated and the relationship between obesity and rectus femoris muscle thickness, sarcopenia, gait and balance will be evaluated.

Diagnostic Test: Ultrasonografi, Sarcopenia measurement, Zebris

Interventions

Ultrasonografi, Sarcopenia measurement, Zebris DIAGNOSTIC_TEST

The rectus femoris muscle thickness of the participants will be performed in B mode via USG (Mindray-UMT 200,USA) with a multifrequency (7-15 MHz) linear probe and the measurement will be reported. TANITA for sarcopenia, hand grip strength and walking speed will be evaluated. Gait time-distance parameters and Static balance COP parameters (COP speed (cm/s) and COP length (cm)) will be recorded using Zebris™ FDM-2.

non-obese women; obese women

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Only women will be included in the study.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The population of the research consists of voluntarily non-obese women residing in Kütahya/Center and obese women voluntarily participating in the study at Kütahya Evliya Çelebi Training and Research Hospital Physical Therapy and Rehabilitation Hospital Obesity School.

You may qualify if:

• Being over 18 years old and female
• Volunteering and accepting to participate in the study
• BMI 30-39.9 kg/m2 in obese women (experimental group)
• BMI 18-27.9 kg/m2 in non-obese women (control group)
• Not having cardiorespiratory, neurological, orthopedic and metabolic disorders

You may not qualify if:

• Being under 18 years old and male
• Having a BMI of 40.0 kg/m2 and above in obese women (experimental group)
• BMI 28.0 kg/m2 and above in non-obese women (control group)
• Having cardiorespiratory, neurological, orthopedic and metabolic disorders

Sponsors & Collaborators

• Kutahya Health Sciences University: lead

Study Sites (1)

Kütahya Health Sciences University

Kütahya, Centre, Turkey (Türkiye)

Location

Related Publications (3)

• Mueller N, Murthy S, Tainter CR, Lee J, Riddell K, Fintelmann FJ, Grabitz SD, Timm FP, Levi B, Kurth T, Eikermann M. Can Sarcopenia Quantified by Ultrasound of the Rectus Femoris Muscle Predict Adverse Outcome of Surgical Intensive Care Unit Patients as well as Frailty? A Prospective, Observational Cohort Study. Ann Surg. 2016 Dec;264(6):1116-1124. doi: 10.1097/SLA.0000000000001546.

  PMID: 26655919 BACKGROUND

• Dutil M, Handrigan GA, Corbeil P, Cantin V, Simoneau M, Teasdale N, Hue O. The impact of obesity on balance control in community-dwelling older women. Age (Dordr). 2013 Jun;35(3):883-90. doi: 10.1007/s11357-012-9386-x. Epub 2012 Feb 10.

  PMID: 22318311 BACKGROUND

• Ates Bulut E, Soysal P, Dokuzlar O, Kocyigit SE, Aydin AE, Yavuz I, Isik AT. Validation of population-based cutoffs for low muscle mass and strength in a population of Turkish elderly adults. Aging Clin Exp Res. 2020 Sep;32(9):1749-1755. doi: 10.1007/s40520-019-01448-4. Epub 2020 Jan 2.

  PMID: 31898170 BACKGROUND

MeSH Terms

Conditions

Sarcopenia; Obesity

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight

Study Officials

• yagmur kuralay

  kütahya health sciences university

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: physiotherapist

Study Record Dates

• First Submitted: November 25, 2022
• First Posted: December 6, 2022
• Study Start: October 15, 2022
• Primary Completion: March 15, 2023
• Study Completion: June 15, 2023
• Last Updated: December 6, 2022

Record last verified: 2022-11

Locations

TU (1)