Chest U/S in Differentiating Lung Congestion & Pneumonia in Adult Critically-ill Patients and Its Prognostic Impact

NCT05636631 | Unknown

• 1 other identifier: chest US for lung conditions
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aim will be to assess the effectiveness of chest ultrasound as a diagnostic and differentiating modality in cases of pneumonia and lung congestion . It also evaluates chests sonography effectiveness in follow-up of patients with pneumonia and lung congestion .

Conditions

Pneumonia; Pulmonary Edema

Outcome Measures

Primary Outcomes (3)

• Diagnostic tool

  Diagnosis of pneumonia vs lung congestion by using chest ultrasound examination viewing A-lines, B-lines, pleural effusion presence \& its initial amount .

  Baseline

• Follow up after initiation of treatment

  Follow up of findings of chest U.S on day 1 after initiating therapy using same parameters ( A-lines, B-lines, pleural effusion) on day 3 of hospital admission

  Baseline ( day 3 of hospital admission)

• Follow up before assessing final outcome

  Follow up of findings of chest U.S on day 1 after initiating therapy using same parameters ( A-lines, B-lines, pleural effusion) on day 7 of hospital admission

  Baseline ( day 7 of hospital admission)

Secondary Outcomes (1)

• morbidity & mortality

  baseline

Study Arms (2)

Patients with Pneumonia (1)

Patients presented with symptoms suggestive of pneumonia as fever, tachypnea, cough with sputum. These patients will receive IV fluids \& antibiotics with follow up of sepsis parameters

Device: Chest ultrasound

Patients with decongestive heart failure (2)

Patients presented with symptoms suggestive of acute congestive heart failure as dyspnea, orthopnea, bilateral lower limb edema. These patients will receive anti-failure treatment as diuretics, ACE inhibitors \& Beta blockers with follow up of resolving signs of decompensated heart failure

Device: Chest ultrasound

Interventions

Chest ultrasound DEVICE

chest ultrasound as a non invasive, low cost \& bedside device for differentiation \& follow up of lung congestion \& pneumonia

Patients with Pneumonia (1); Patients with decongestive heart failure (2)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

both genders adult (above age of 18 years) critically ill patients

You may qualify if:

• Adult (above 18 years old)
• Both genders
• Patient with symptoms suggestive of pneumonia
• Patient with symptoms suggestive of acute congestive heart failure
• admitted to Critical care unit

You may not qualify if:

• Patients with Renal induced lung congestion

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Nardin Aymn

Asyut, Asyut Governorate, 71511, Egypt

RECRUITING

Related Publications (2)

• Volpicelli G, Cardinale L, Garofalo G, Veltri A. Usefulness of lung ultrasound in the bedside distinction between pulmonary edema and exacerbation of COPD. Emerg Radiol. 2008 May;15(3):145-51. doi: 10.1007/s10140-008-0701-x. Epub 2008 Jan 31.

  PMID: 18236088 BACKGROUND

• Lichtenstein DA. BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill. Chest. 2015 Jun;147(6):1659-1670. doi: 10.1378/chest.14-1313.

  PMID: 26033127 BACKGROUND

MeSH Terms

Conditions

Pneumonia; Pulmonary Edema

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Mahmoud Ashry, Professor

  Professor Faculty of Medicine, Assiut University

  STUDY DIRECTOR

Central Study Contacts

Nardin Aymn, resident

CONTACT

01285151220; Nardeen.14223960@med.aun.edu.eg

Alaa Ahmed, lecturer

CONTACT

alaa_omar11@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: November 4, 2022
• First Posted: December 5, 2022
• Study Start: November 1, 2022
• Primary Completion: November 30, 2024
• Study Completion: July 31, 2025
• Last Updated: December 5, 2022

Record last verified: 2022-12

Locations

EG (1)