Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio in Predicting the Incidence of Nausea and Vomiting

NCT05636163 | Unknown

• 1 other identifier: neutrophil-to-lymphocyte ratio
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

By comparing the incidence of PONV, the dosage of postoperative antiemetic drugs, the postoperative VAS score and the utilization rate of PCIA of hemophilia A patients in the NLR≥2 and NLR\<2 groups, investigators could find out the high value in the diagnosis of hemophilia A, which is helpful to guide the clinical diagnosis and treatment of hemophilia A.

Conditions

Hemophilia A

Keywords

Neutrophil; Lymphocyte; Platelet; Hemophilia; Post-operative nausea and vomiting

Outcome Measures

Primary Outcomes (1)

• Incidence of PONV in patients with hemophilia A receiving general anesthesia orders for knee arthroplasty

  PONV was defined as the onset of nausea or vomiting within 24 hours after surgery

  up to 24 hours after surgery

Secondary Outcomes (3)

• The amount of postoperative antiemetics

  up to 24 hours after surgery

• VAS score after returning to the ward

  immediately after returning to the ward

• Usage of PCIA

  up to 24 hours after surgery

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hemophilia A patients who underwent single knee replacement under general anesthesia in the First Affiliated Hospital of Shandong First Medical University from March 2018 to February 2022

You may qualify if:

• The patients with hemophilia A undergoing unilateral total knee arthroplasty.
• The age of the patients ranged from 18 to 70 years.
• American Society of Anesthesiologists is graded as I\~III
• No history of mental illness
• No history of antiemetic and anticholinergic drugs.
• No history of serious gastrointestinal diseases.

You may not qualify if:

• Patients who have received long-term steroid treatment
• Patients who need more than 2.5 mg neostigmine to reverse muscle relaxants
• Patients with previous malignant tumor, malabsorption, morbid obesity, hypogonadism, thyroid and parathyroid diseases and autoimmune diseases.

Sponsors & Collaborators

• Qianfoshan Hospital: lead

Study Sites (1)

Shandong Provincial Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University

Jinan, Shandong, 250000, China

Location

MeSH Terms

Conditions

Hemophilia A; Vomiting

Condition Hierarchy (Ancestors)

Blood Coagulation Disorders, Inherited; Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Coagulation Protein Disorders; Hemorrhagic Disorders; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Yuelan Wang

  China, Shandong Qianfoshan Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yuelan Wang

CONTACT

15953105780; wyldgf@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 17, 2022
• First Posted: December 5, 2022
• Study Start: December 15, 2022
• Primary Completion: January 20, 2023
• Study Completion: February 20, 2023
• Last Updated: December 5, 2022

Record last verified: 2022-12

Locations

CN (1)