Uric Acid Based Renal Stones: Clinical, Metabolic and Genetic Characterization

NCT05634434 | Unknown

• 1 other identifier: MS.21.08.1617
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

• Reporting prevalence of uric acid based renal stones among patients with nephrolithiasis admitted to Mansoura Urology and Nephrology center (MUNC).
• Furthermore, identification of monogenic and polygenic uric acid stone formers.
• Identification of factors associated uric acid stone recurrence as well as determinants of laterality in patients with uric acid based renal stones

Conditions

Renal Stone; Urinary Stones

Keywords

kidney stones; uric acid

Outcome Measures

Primary Outcomes (1)

• reporting overall prevalence of uric acid stones

  reporting overall prevalence of uric acid stones among patients with renal stones admitted in Mansoura UNC during study period.

  1 year

Secondary Outcomes (1)

• identification of genetic alterations in patients with uric acid stones

  1year

Study Arms (2)

control group

Same patient, stone free kidney

Study group

uric acid stone former, diseased kidney (stone harboring)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Uric acid-based renal stone formers * Denovo uric acid stone former (DUASF) * Recurrent uric acid stone former (RUASF)

You may qualify if:

• ⦁ Patients with unilateral renal stones (denovo or recurrent) who are candidates for endoscopic treatment (percutaneous nephrolithotomy).
• Patients with preoperative NCCT findings of renal stone with stone density equal or less than 600HU.
• Patients with dominant uric acid composition will be included as proven by postoperative stone analysis

You may not qualify if:

• ⦁ Patients with anatomical abnormalities precipitating stone disease e.g. ureteric stricture, ureteropelvic or ureterovesical junction obstruction, Urinary diversion, History of ureterovesical re-implantation
• Patients with non-uric acid stones as proven by post-operative stone analysis.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Urology and nephrology center

Al Mansurah, DK, 35516, Egypt

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

urine samples were collected from the renal pelvis of the kidney using ureteric catheter

MeSH Terms

Conditions

Nephrolithiasis; Urinary Calculi; Kidney Calculi

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Ahmed Elshal, MD

  Mansoura University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ahmed M elshal, PHD

CONTACT

00201001855490; elshalam@hotmail.com

Islam M hawash, MD student

CONTACT

00201091762964; islamhawash3@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Urology

Study Record Dates

• First Submitted: November 22, 2022
• First Posted: December 2, 2022
• Study Start: October 1, 2021
• Primary Completion: December 30, 2022
• Study Completion: October 1, 2023
• Last Updated: December 2, 2022

Record last verified: 2022-11

Locations

EG (1)