UNC Pleural Fluid Registry

NCT05620329 | Recruiting

• 1 other identifier: LCCC1754
• Study Type: observational
• Target: 9,999
• Locations: 1 country
• Sites: 1

Brief Summary

Research with biospecimens such as blood, tissue, or body fluids can help researchers understand how the human body works. Researchers can make new tests to find diseases, understand how treatments work, or find new ways to treat a disease. The purpose of this study is to collect biospecimens for research from patients with known or suspected lung cancer. The information learned from the biospecimens may be used in future treatments. The purpose of this protocol is to create a pleural fluid registry for use in future studies.

Conditions

Lung Cancer; Lung Infection; Breast Cancer; Malignant Pleural Effusion; Empyema

Keywords

biospecimen; pleural fluid; lung cancer; cancer; infection; breast cancer

Outcome Measures

Primary Outcomes (1)

• Creation of a pleural fluid registry

  Biological specimens and corresponding clinical data from subjects will be collected during standard of care procedures and medical record abstraction to support the creation of a pleural fluid registry.

  32 years

Study Arms (1)

Pleural Fluid Registry

Any subject who has pleural fluid buildup from lung cancer, breast cancer, or lung infection

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

UNC patients

You may qualify if:

• Patients who are 18 years or older
• Inpatients and outpatients
• Diagnosed with pleural fluid, are referred for and undergo clinically indicated drainage who have clinical evidence of:
• pulmonary infection (such as fever, leukocytosis, new or worsening infiltrate on chest x-ray, or clinical deterioration) with effusion
• malignancy

You may not qualify if:

• Incarcerated individuals

Sponsors & Collaborators

• UNC Lineberger Comprehensive Cancer Center: lead

Study Sites (1)

UNC Lingeberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

RECRUITING

Related Links

• University of North Carolina Lineberger Comprehensive Cancer Center Clinical Trials

Biospecimen

Retention: SAMPLES WITH DNA

Blood and pleural fluid

MeSH Terms

Conditions

Lung Neoplasms; Breast Neoplasms; Pleural Effusion, Malignant; Empyema; Neoplasms; Infections

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Lung Diseases; Respiratory Tract Diseases; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Pleural Neoplasms; Pleural Effusion; Pleural Diseases; Suppuration; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jason Akulian

  UNC Lineberger Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Carmmen Garcia

CONTACT

+1 954-336-7499; carmmene@med.unc.edu

Luz Cuaboy

CONTACT

+1 954-336-7499; luz_cuaboy@med.unc.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 32 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 9, 2022
• First Posted: November 17, 2022
• Study Start: January 24, 2018
• Primary Completion (Estimated): January 24, 2050
• Study Completion (Estimated): January 24, 2050
• Last Updated: October 16, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)